Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Autor: Antonio Schiattarella, Marco La Verde, Luigi Cobellis, Raffaele Autiero, Luigi Della Corte, Antonio Simone Laganà, Simone Garzon, Federico Licciardi, Gaetano Riemma, Pasquale De Franciscis
Přispěvatelé: Riemma, G., Lagana, A. S., Schiattarella, A., Garzon, S., Cobellis, L., Autiero, R., Licciardi, F., Corte, L. D., La Verde, M., De Franciscis, P., Riemma, Gaetano, Simone Laganà, Antonio, Schiattarella, Antonio, Garzon, Simone, Cobellis, Luigi, Autiero, Raffaele, Licciardi, Federico, DELLA CORTE, Luigi, La Verde, Marco, De Franciscis, Pasquale
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Aquaporin
CFTR
Chloride channels
Endometriosis
Etiology
Ion channels
Pathogenesis
0301 basic medicine
MAPK/ERK pathway
endometriosis
Review
lcsh:Chemistry
0302 clinical medicine
ion channels
etiology
pathogenesis
aquaporin
chloride channels
Endometriosi
lcsh:QH301-705.5
Spectroscopy
030219 obstetrics & reproductive medicine
biology
Chemistry
General Medicine
cftr
Cystic fibrosis transmembrane conductance regulator
Computer Science Applications
Chloride channel
Female
Signal transduction
Ion channel
Signal Transduction
CFTR
aquaporin
chloride channels
endometriosis
etiology
ion channels
pathogenesis
Aquaporins
Catalysis
Inorganic Chemistry
03 medical and health sciences
medicine
Animals
Humans
Physical and Theoretical Chemistry
Protein kinase A
Molecular Biology
Protein kinase B
PI3K/AKT/mTOR pathway
Organic Chemistry
medicine.disease
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
Cancer research
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 3, p 1114 (2020)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Background: Ion channels play a crucial role in many physiological processes. Several subtypes are expressed in the endometrium. Endometriosis is strictly correlated to estrogens and it is evident that expression and functionality of different ion channels are estrogen-dependent, fluctuating between the menstrual phases. However, their relationship with endometriosis is still unclear. Objective: To summarize the available literature data about the role of ion channels in the etiopathogenesis of endometriosis. Methods: A search on PubMed and Medline databases was performed from inception to November 2019. Results: Cystic fibrosis transmembrane conductance regulator (CFTR), transient receptor potentials (TRPs), aquaporins (AQPs), and chloride channel (ClC)-3 expression and activity were analyzed. CFTR expression changed during the menstrual phases and was enhanced in endometriosis samples; its overexpression promoted endometrial cell proliferation, migration, and invasion throughout nuclear factor kappa-light-chain-enhancer of activated B cells-urokinase plasminogen activator receptor (NFκB-uPAR) signaling pathway. No connection between TRPs and the pathogenesis of endometriosis was found. AQP5 activity was estrogen-increased and, through phosphatidylinositol-3-kinase and protein kinase B (PI3K/AKT), helped in vivo implantation of ectopic endometrium. In vitro, AQP9 participated in extracellular signal-regulated kinases/p38 mitogen-activated protein kinase (ERK/p38 MAPK) pathway and helped migration and invasion stimulating matrix metalloproteinase (MMP)2 and MMP9. ClC-3 was also overexpressed in ectopic endometrium and upregulated MMP9. Conclusion: Available evidence suggests a pivotal role of CFTR, AQPs, and ClC-3 in endometriosis etiopathogenesis. However, data obtained are not sufficient to establish a direct role of ion channels in the etiology of the disease. Further studies are needed to clarify this relationship.
Databáze: OpenAIRE
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