Specific metabolic markers are associated with future waist-gaining phenotype in women

Autor: Karsten Suhre, Tobias Pischon, Rui Wang-Sattler, Barbara Thorand, Marjolein Haftenberger, Anna Floegel, Jerzy Adamski, Harald Grallert, Ursula Bachlechner, Simone Wahl, Annette Peters, Benedikt Merz, Anja Schienkiewitz, Heiner Boeing, Ute Nöthlings
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Physiology
Metabolite
lcsh:Medicine
Weight Gain
Biochemistry
Body Mass Index
Cohort Studies
Fats
chemistry.chemical_compound
0302 clinical medicine
Metabolites
Medicine and Health Sciences
030212 general & internal medicine
lcsh:Science
Musculoskeletal System
Multidisciplinary
Confounding
Middle Aged
Circumference
Lipids
Phenotype
Physiological Parameters
Metabolome
Female
Waist Circumference
Anatomy
medicine.symptom
Research Article
Adult
medicine.medical_specialty
Waist
030209 endocrinology & metabolism
Pelvis
03 medical and health sciences
Meta-Analysis as Topic
Internal medicine
medicine
Humans
Metabolomics
Obesity
Aged
Hip
Waist-Hip Ratio
business.industry
Body Weight
lcsh:R
Biology and Life Sciences
Odds ratio
medicine.disease
Metabolism
Endocrinology
chemistry
Cardiovascular and Metabolic Diseases
lcsh:Q
business
Body mass index
Weight gain
Biomarkers
Zdroj: PLoS ONE 11:e0157733 (2016)
PLOS ONE, 11(6): e0157733
PLoS ONE, Vol 11, Iss 6, p e0157733 (2016)
PLoS ONE
Popis: OBJECTIVE: Our study aims to identify metabolic markers associated with either a gain in abdominal (measured by waist circumference) or peripheral (measured by hip circumference) body fat mass. METHODS: Data of 4 126 weight-gaining adults (18-75 years) from three population-based, prospective German cohort studies (EPIC, KORA, DEGS) were analysed regarding a waist-gaining (WG) or hip-gaining phenotype (HG). The phenotypes were obtained by calculating the differences of annual changes in waist minus hip circumference. The difference was displayed for all cohorts. The highest 10% of this difference were defined as WG whereas the lowest 10% were defined as HG. A total of 121 concordant metabolite measurements were conducted using Biocrates AbsoluteIDQ® kits in EPIC and KORA. Sex-specific associations with metabolite concentration as independent and phenotype as the dependent variable adjusted for confounders were calculated. The Benjamini-Hochberg method was used to correct for multiple testing. RESULTS: Across studies both sexes gained on average more waist than hip circumference. We could identify 12 metabolites as being associated with the WG (n = 8) or HG (n = 4) in men, but none were significant after correction for multiple testing; 45 metabolites were associated with the WG (n = 41) or HG (n = 4) in women. For WG, n = 21 metabolites remained significant after correction for multiple testing. Respective odds ratios (OR) ranged from 0.66 to 0.73 for tryptophan, the diacyl-phosphatidylcholines (PC) C32:3, C36:0, C38:0, C38:1, C42:2, C42:5, the acyl-alkyl-PCs C32:2, C34:0, C36:0, C36:1, C36:2, C38:0, C38:2, C40:1, C40:2, C40:5, C40:6, 42:2, C42:3 and lyso-PC C17:0. CONCLUSION: Both weight-gaining men and women showed a clear tendency to gain more abdominal than peripheral fat. Gain of abdominal fat seems to be related to an initial metabolic state reflected by low concentrations of specific metabolites, at least in women. Thus, higher levels of specific PCs may play a protective role in gaining waist circumference.
Databáze: OpenAIRE
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