Specific metabolic markers are associated with future waist-gaining phenotype in women
Autor: | Karsten Suhre, Tobias Pischon, Rui Wang-Sattler, Barbara Thorand, Marjolein Haftenberger, Anna Floegel, Jerzy Adamski, Harald Grallert, Ursula Bachlechner, Simone Wahl, Annette Peters, Benedikt Merz, Anja Schienkiewitz, Heiner Boeing, Ute Nöthlings |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Male
Physiology Metabolite lcsh:Medicine Weight Gain Biochemistry Body Mass Index Cohort Studies Fats chemistry.chemical_compound 0302 clinical medicine Metabolites Medicine and Health Sciences 030212 general & internal medicine lcsh:Science Musculoskeletal System Multidisciplinary Confounding Middle Aged Circumference Lipids Phenotype Physiological Parameters Metabolome Female Waist Circumference Anatomy medicine.symptom Research Article Adult medicine.medical_specialty Waist 030209 endocrinology & metabolism Pelvis 03 medical and health sciences Meta-Analysis as Topic Internal medicine medicine Humans Metabolomics Obesity Aged Hip Waist-Hip Ratio business.industry Body Weight lcsh:R Biology and Life Sciences Odds ratio medicine.disease Metabolism Endocrinology chemistry Cardiovascular and Metabolic Diseases lcsh:Q business Body mass index Weight gain Biomarkers |
Zdroj: | PLoS ONE 11:e0157733 (2016) PLOS ONE, 11(6): e0157733 PLoS ONE, Vol 11, Iss 6, p e0157733 (2016) PLoS ONE |
Popis: | OBJECTIVE: Our study aims to identify metabolic markers associated with either a gain in abdominal (measured by waist circumference) or peripheral (measured by hip circumference) body fat mass. METHODS: Data of 4 126 weight-gaining adults (18-75 years) from three population-based, prospective German cohort studies (EPIC, KORA, DEGS) were analysed regarding a waist-gaining (WG) or hip-gaining phenotype (HG). The phenotypes were obtained by calculating the differences of annual changes in waist minus hip circumference. The difference was displayed for all cohorts. The highest 10% of this difference were defined as WG whereas the lowest 10% were defined as HG. A total of 121 concordant metabolite measurements were conducted using Biocrates AbsoluteIDQ® kits in EPIC and KORA. Sex-specific associations with metabolite concentration as independent and phenotype as the dependent variable adjusted for confounders were calculated. The Benjamini-Hochberg method was used to correct for multiple testing. RESULTS: Across studies both sexes gained on average more waist than hip circumference. We could identify 12 metabolites as being associated with the WG (n = 8) or HG (n = 4) in men, but none were significant after correction for multiple testing; 45 metabolites were associated with the WG (n = 41) or HG (n = 4) in women. For WG, n = 21 metabolites remained significant after correction for multiple testing. Respective odds ratios (OR) ranged from 0.66 to 0.73 for tryptophan, the diacyl-phosphatidylcholines (PC) C32:3, C36:0, C38:0, C38:1, C42:2, C42:5, the acyl-alkyl-PCs C32:2, C34:0, C36:0, C36:1, C36:2, C38:0, C38:2, C40:1, C40:2, C40:5, C40:6, 42:2, C42:3 and lyso-PC C17:0. CONCLUSION: Both weight-gaining men and women showed a clear tendency to gain more abdominal than peripheral fat. Gain of abdominal fat seems to be related to an initial metabolic state reflected by low concentrations of specific metabolites, at least in women. Thus, higher levels of specific PCs may play a protective role in gaining waist circumference. |
Databáze: | OpenAIRE |
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