Neuronal Dysexcitability May Be a Biomarker of Migraine: A Visual Evoked Potential Study
| Autor: | Usha K. Misra, Ravi Uniyal, Jayantee Kalita, Sanjeev K. Bhoi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent genetic structures Photophobia Migraine Disorders Audiology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Evoked potential Habituation Habituation Psychophysiologic Sensitization business.industry Headache Electroencephalography General Medicine Middle Aged medicine.disease 030104 developmental biology Allodynia Phonophobia medicine.anatomical_structure Neurology Migraine Evoked Potentials Visual Biomarker (medicine) Female Neurology (clinical) medicine.symptom business Biomarkers Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Clinical EEG and Neuroscience. 49:342-350 |
| ISSN: | 2169-5202 1550-0594 |
| DOI: | 10.1177/1550059417734106 |
| Popis: | We report neuronal sensitization and impaired habituation in migraine using pattern reversal visual evoked potential (PRVEP) and correlate these with clinical characteristics of migraine. Sixty-five migraineurs and 30 healthy controls were included. A detailed clinical examination was done and migraine characteristics, including migraine trigger, photophobia, phonophobia, and allodynia were noted. Consecutive 5 blocks of PRVEP were recorded averaging 100 epochs at 3 Hz stimuli. The amplitude of N75 and P100 were measured. Amplitude of first block was considered for sensitization, and impaired habituation was considered if any subsequent block was not suppressed. Migraineurs had sensitization of P100 (14.01 ± 6.02 vs 11.60 ± 5.17 µV; P = .049), but not of N75 (42.22 ± 4.79 vs 11.08 ± 4.56 µV; P = .27) compared with the controls. Impaired habituation of N75 was more marked and persisted up to fourth block of VEP recoding. Impaired habituation of P100 was significant only in the third block. Baseline N75 and P100 amplitudes were higher in females, and N75 was also higher in those with longer duration of illness. These phenomena did not correlate with visual triggers. Sensitization and impaired habituation were marked during headache. Based on the PRVEP findings, it may be concluded that migraineurs have sensitization of P100 and impaired habituation of N75 especially during headache. These phenomena may be useful for therapeutic monitoring. |
| Databáze: | OpenAIRE |
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