Hyperbaric Oxygen Therapy as Concurrent Treatment with Systemic Steroids for Idiopathic Sudden Sensorineural Hearing Loss: A Comparison of Three Different Steroid Treatments

Autor: Hiroyuki Mineta, Seiji Hosokawa, Hiroshi Nakanishi, Satoru Takebayashi, Kenichi Sugiyama, Goro Takahashi, Kumiko Hosokawa
Rok vydání: 2018
Předmět:
Male
Physiology
Administration
Oral
Comorbidity
0302 clinical medicine
Hearing
Vertigo
030223 otorhinolaryngology
Aged
80 and over
Hyperbaric Oxygenation
Injection
Intratympanic
biology
Hearing Tests
Smoking
Middle Aged
Prognosis
Combined Modality Therapy
Sensory Systems
Treatment Outcome
Hearing level
030220 oncology & carcinogenesis
Anesthesia
Sudden sensorineural hearing loss
Hypertension
Female
Adult
Adolescent
Hearing Loss
Sensorineural
Steroid treatments
Young Adult
03 medical and health sciences
Speech and Hearing
Hyperbaric oxygen
Patient age
Diabetes mellitus
Diabetes Mellitus
otorhinolaryngologic diseases
medicine
Humans
Glucocorticoids
Aged
Retrospective Studies
business.industry
Recovery of Function
Hearing Loss
Sudden
medicine.disease
biology.organism_classification
Otorhinolaryngology
Complication
business
Zdroj: Audiology and Neurotology. 23:145-151
ISSN: 1421-9700
1420-3030
DOI: 10.1159/000493083
Popis: We analyzed 356 patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and systemic steroids (n = 161), systemic steroids alone (n = 160), or intratympanic and systemic steroids (n = 35). The main outcome measure was the hearing recovery rate. The effect of other variables, including the initial averaged 5-frequency hearing level, patient age, interval between the onset of symptoms and treatment, presence of vertigo as a complication, presence of diabetes mellitus, smoking history, and presence of hypertension, on the hearing recovery rate was also evaluated. The overall hearing recovery rate was significantly higher for the patients treated with hyperbaric oxygen therapy and systemic steroids than for those treated with systemic steroids alone (p < 0.001) or systemic and intratympanic steroids (p < 0.001). The presence of vertigo negatively affected hearing recovery. Our findings suggest that hyperbaric oxygen therapy confers a significant additional therapeutic benefit when used in combination with steroid therapy for idiopathic sudden sensorineural hearing loss.
Databáze: OpenAIRE
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