Association of familial history of diabetes or myocardial infarction and stroke with risk of cardiovascular diseases in four German cohorts

Autor:	Matthias B. Schulze, Alexander Kluttig, Cornelia Weikert, Till Ittermann, Christa Meisinger, Daniel Medenwald, Manuela M. Bergmann, Juliane Menzel, Annette Peters, Kristin Mühlenbruch, Heiner Boeing, Marcus Dörr
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Epidemiology Myocardial Infarction lcsh:Medicine Type 2 diabetes 030204 cardiovascular system & hematology Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine medicine Humans ddc:610 Prospective Studies cardiovascular diseases Family history Risk factor lcsh:Science Stroke Triglycerides Risk factors Aged Proportional Hazards Models Multidisciplinary business.industry Incidence Hazard ratio lcsh:R Middle Aged medicine.disease Diabetes Mellitus Type 2 Cardiovascular Diseases Cohort Female lcsh:Q business 030217 neurology & neurosurgery Cohort study
Zdroj:	Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Sci. Rep. 10:15373 (2020) Scientific reports, 10(1):15373 Scientific Reports
ISSN:	2045-2322
DOI:	10.1038/s41598-020-72361-4
Popis:	Since family history of diabetes is a very strong risk factor for type 2 diabetes, which is one of the most important risk factors for cardiovascular disease (CVD), it might be also useful to assess the risk for CVD. Therefore, we aimed to investigate the relationship between a familial (parents and siblings) history of diabetes and the risk of incident CVD. Data from four prospective German cohort studies were used: EPIC-Potsdam study (n = 26,054), CARLA study (n = 1,079), SHIP study (n = 3,974), and KORA study (n = 15,777). A multivariable-adjusted Cox regression was performed to estimate associations between familial histories of diabetes, myocardial infarction or stroke and the risk of CVD in each cohort; combined hazard ratios (HRMeta) were derived by conducting a meta-analysis. The history of diabetes in first-degree relatives was not related to the development of CVD (HRMeta 0.99; 95% CI 0.88–1.10). Results were similar for the single outcomes myocardial infarction (MI) (HRMeta 1.07; 95% CI 0.92–1.23) and stroke (HRMeta 1.00; 95% CI 0.86–1.16). In contrast, parental history of MI and stroke were associated with an increased CVD risk. Our study indicates that diabetes in the family might not be a relevant risk factor for the incidence of CVD. However, the study confirmed the relationship between a parental history of MI or stroke and the onset of CVD.
Databáze:	OpenAIRE
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