Prevalence of genital abnormalities in neonates
| Autor: | Erisvaldo F. Cavalcante Júnior, Paula D. Pereira, Maricilda Palandi de Mello, Ana Thaysa V. S. de Mendonça, Isabella Lopes Monlleó, Débora de Paula Michelatto, Maria Deysiane P. Araújo, Paulo M. de Barros, Ylana R. dos Santos, Bárbara Priscila B. de Araújo, Andréa Trevas Maciel-Guerra, Gil Guerra-Júnior, Catarina R. S. Santos, Susane Vasconcelos Zanotti |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Disorders of Sex Development Neonatal Screening Prevalence medicine Humans Sex organ Genital abnormality Hypospadias business.industry Obstetrics Enlarged clitoris Infant Newborn Case-control study Micropenis Labia majora medicine.disease medicine.anatomical_structure Case-Control Studies Pediatrics Perinatology and Child Health Genital Ambiguity Female Live birth business Brazil |
| Zdroj: | Jornal de Pediatria. 88:489-95 |
| ISSN: | 0021-7557 |
| DOI: | 10.2223/jped.2237 |
| Popis: | Objectives To assess the prevalence of genital abnormalities among neonates in two public maternity-schools. Methods Case-control, cross-sectional descriptive study. Genital morphology of 2,916 neonates was assessed using a clinical protocol between 04/19/2010 and 04/18/2011. Control group included neonates without birth defects, born at the same maternity unit and in the same day in which a case was identified. Fisher and Kruskal-Wallis tests were used for statistics. Results The study identified 29 (1:100) neonates with genital abnormalities. Most of them were examined within 3 days of life and presented only one genital defect. Morphological abnormalities comprised: genital ambiguity (1/29), fusion of labia majora (1/29), micropenis (2/29), enlarged clitoris (6/29), hypospadia (9/29), and combined defects (4/29). Only one case reported the genital abnormality in the statement of live birth correctly. Prematurity occurred in 13/29 cases and was the only variable statistically associated with genital defects. Eight cases agreed on the complementary investigation of the genital defect, among which three were diagnosed with disorder of sex development. Conclusions There is a high prevalence of genital abnormalities in the maternity units included in the present study and most cases are under-diagnosed and under-reported. Our results reinforce the importance of a careful examination of genital morphology in neonatal period towards the recognition of minor defects that can be clinical features of a disorder of sex development. |
| Databáze: | OpenAIRE |
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