The common fragile site in band q27 of the human X chromosome is not coincident with the fragile X
| Autor: | Grant R. Sutherland, Elizabeth Baker |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
Genetics medicine.medical_specialty Fragile x X Chromosome Chromosome Fragile Sites Chromosome Fragility Chromosomal fragile site Cytogenetics X fragile syndrome Karyotype Biology Long arm medicine.disease Chromosome Banding Diagnosis Differential Fragile X syndrome Fragile X Syndrome medicine Humans False Positive Reactions Sex Chromosome Aberrations Genetics (clinical) X chromosome |
| Zdroj: | Clinical Genetics. 37:167-172 |
| ISSN: | 1399-0004 0009-9163 |
| DOI: | 10.1111/j.1399-0004.1990.tb03498.x |
| Popis: | The common fragile site on the end of the long arm of the human X chromosome has been shown to be at a different location from the rare fragile site which produces the fragile X syndrome of intellectual handicap. The different locations can be clearly seen in chromosomes at about the 550 band level of resolution. This finding should help resolve difficulties in fragile X cytogenetics where expression of the common fragile site can lead to false positive diagnoses. |
| Databáze: | OpenAIRE |
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