A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region
| Autor: | M.A. Nesbit, H. Paterson, Nicholas Owen, Yvonne Boyd, E. McLellan-Arnold, Nanda R. Rodrigues, Kay E. Davies, M. A. Leversha, Derek J. Blake, A M Theodosiou, Alan Ashworth, Helen J. Ambrose |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
DNA
Complementary Microinjections Transcription Genetic Molecular Sequence Data Biology Transfection Homology (biology) Mice Open Reading Frames Trinucleotide Repeats Gene mapping Sequence Homology Nucleic Acid Gene expression Genetics Animals Humans Coding region Gene family Amino Acid Sequence RNA Messenger Molecular Biology Gene In Situ Hybridization Fluorescence Genetics (clinical) Brain Chemistry Chromosome 7 (human) Base Sequence Sequence Homology Amino Acid Chromosomes Human Pair 10 Chromosomes Human Pair 11 General Medicine Blotting Northern Molecular biology Protein Biosynthesis Protein Tyrosine Phosphatases Trinucleotide repeat expansion Signal Transduction Subcellular Fractions |
| DOI: | 10.1093/hmg/5.5.675 |
| Popis: | We have identified a novel mouse gene encoding a protein that shows high homology to the dual-specificity tyrosine/threonine phosphatase family of proteins. The gene encodes a 5 kb transcript which is expressed predominantly in brain and lung and contains a translated complex trinucleotide repeat within the coding region. Using interspecific mouse backcross analysis, the gene has been localised to distal mouse chromosome 7. In human, homologous sequences are located in the syntenic region on distal chromosome 11p as well as to chromosome 10q11.2 and 10q22. The presence of a CG-rich trinucleotide repeat in the coding region provides a target for mutation which might result in loss of function or altered properties of this phosphatase. |
| Databáze: | OpenAIRE |
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