Effects of immunosuppressive drugs on the cognitive functioning of renal transplant recipients: A pilot study
| Autor: | M Consuelo Bernal, José Vicente Montagud, A. Sancho, Josep Crespo, Sonia Martínez-Sanchis, Gemma Candela, Luis M Pallardó |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Graft Rejection Male Sleep Wake Disorders medicine.medical_specialty Pilot Projects Neuropsychological Tests Developmental psychology Young Adult Surveys and Questionnaires Internal medicine medicine Humans Neuropsychological assessment Cognitive deficit Psychiatric Status Rating Scales Analysis of Variance medicine.diagnostic_test Cognition Middle Aged Kidney Transplantation Tacrolimus Transplantation Clinical Psychology surgical procedures operative Mood Neurology Sirolimus Quality of Life Kidney Failure Chronic Anxiety Female Neurology (clinical) medicine.symptom Cognition Disorders Psychology Immunosuppressive Agents Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Clinical and Experimental Neuropsychology. 33:1016-1024 |
| ISSN: | 1744-411X 1380-3395 |
| DOI: | 10.1080/13803395.2011.595396 |
| Popis: | Some renal transplant patients show cognitive, emotional, and behavioral changes as part of possible neurotoxic effects associated with immunosuppressive medication, especially tacrolimus. This study evaluated effects of immunosuppressive drugs on some cognitive tasks. Patients treated with sirolimus and cyclosporine reported some of the noncognitive side effects related to immunosuppressive treatment. We observed attention and working memory impairment in patients treated with sirolimus or tacrolimus. Performance of cyclosporine-treated subjects was similar to that of healthy volunteer controls. Since the mood, anxiety, and sleep patterns measured were unaffected, it could be concluded that the cognitive deficit found was partly related to treatment. |
| Databáze: | OpenAIRE |
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