Tissue Conversion of Thyroxine to Triiodothyronine

Autor:	Margaret K. Berg, Robert H. Williams, John R. Hogness, Paul P. Van Arsdel
Rok vydání:	1955
Předmět:	medicine.medical_specialty Kidney Triiodothyronine Muscles Butanol Fractionation General Biochemistry Genetics and Molecular Biology Thyroxine chemistry.chemical_compound Endocrinology medicine.anatomical_structure Liver metabolism Liver chemistry Internal medicine medicine Spleen
Zdroj:	Experimental Biology and Medicine. 90:93-97
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-90-21949
Popis:	Summary(1) I131-labeled thyroxine was administered intravenously to normal and thyroidectomized rats and the animals sacrificed at varying time intervals thereafter. Specimens of liver, kidney and muscle were homogenized, extracted with butanol and the extracts were subjected to kieselguhr chromatographic analysis. Small amounts of triiodothyronine were recovered from all 3 tissues in about 20% of the analyses carried out. (2) When triiodothyronine was administered and the tissues subjected to the same conditions, no thyroxine was recovered. (3) When the tissues of rats given thyroxine were homogenized and subjected to fractionation into their subcellular components, triiodothyronine was more readily recovered than was the case where the whole homogenate was used. A possible explanation for this is discusses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6d0e02ed8f24e0146b84680b86842c https://doi.org/10.3181/00379727-90-21949 Zobrazit plný text záznamu