Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study
| Autor: | Helen, Kovari, Bruno, Ledergerber, Ulrich, Peter, Markus, Flepp, Josef, Jost, Patrick, Schmid, Alexandra, Calmy, Nicolas J, Mueller, Beat, Muellhaupt, Rainer, Weber, S, Yerly |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Cirrhosis Anti-HIV Agents HIV Infections Gastroenterology Internal medicine Antiretroviral Therapy Highly Active Hypertension Portal medicine Humans Didanosine Reverse-transcriptase inhibitor business.industry Odds ratio Middle Aged medicine.disease Infectious Diseases Nelfinavir Case-Control Studies Nested case-control study Immunology Ritonavir Female Lipodystrophy business medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 49(4) |
| ISSN: | 1537-6591 |
| Popis: | BACKGROUND: Noncirrhotic portal hypertension (NCPH) is a newly described life-threatening liver disease of unknown cause in human immunodeficiency virus (HIV)-infected persons. Postulated pathogenesis includes prolonged exposure to antiretroviral therapy, particularly didanosine. METHODS: We performed a nested case-control study including 15 patients with NCPH and 75 matched control subjects of the Swiss HIV Cohort Study to investigate risk factors for the development of NCPH. Matching criteria were similar duration of HIV infection, absence of viral hepatitis, and follow-up to at least the date of NCPH diagnosis in the respective case. RESULTS: All 15 case patients had endoscopically documented esophageal varices and absence of liver cirrhosis on biopsies; 4 died because of hepatic complications. At NCPH diagnosis, case patients and control subjects were similar concerning sex; race; Centers for Disease Control and Prevention stage; HIV-RNA level; CD4 cell count nadir; and lipids and lipodystrophy. Differences were found in age (conditional logistic regression odds ratio [OR] for 10 years older, 2.9; 95% confidence interval [CI], 1.4-6.1); homosexuality (OR, 4.5; 95% CI, 1.2-17); current CD4 cell count |
| Databáze: | OpenAIRE |
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