Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis
| Autor: | Guican Zhang, Hitonobu Tomoike, Masakazu Yamagishi, Kunio Miyatake, Teruo Tachibana, Fumio Ohmori, Satoshi Nakatani, Masafumi Kitakaze, Chiung-Zuan Chiu |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Time Factors Sarcoidosis medicine.drug_class Prednisolone Contractility Internal medicine medicine Humans In patient cardiovascular diseases Ventricular remodeling Glucocorticoids Aged Retrospective Studies Ejection fraction Ventricular Remodeling business.industry Retrospective cohort study Middle Aged medicine.disease cardiovascular system Cardiology Corticosteroid Female Cardiomyopathies Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 95:143-146 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2004.08.083 |
| Popis: | Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejection fractions (LVEFs)or=55%, long-term steroid therapy showed preventive effects for LV remodeling and LV function. Patients with LVEF54% showed significant reductions of LV volumes and LVEF improvement. However, in patients with LVEFs30%, steroid therapy resulted in neither LV volume reductions nor improved LVEFs. In the early or middle stage of the disease, steroid therapy may be protective or therapeutic in preventing LV remodeling and preserving LV function. However, it may not be as effective in the late stage. |
| Databáze: | OpenAIRE |
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