Porous Silicon-Based Nanomedicine for Simultaneous Management of Joint Inflammation and Bone Erosion in Rheumatoid Arthritis

Autor:	Moonkyoung Jeong, Yuna Jung, Junyong Yoon, Jinyoung Kang, Seo Hyeon Lee, Woojin Back, Hyoyeon Kim, Michael J. Sailor, Dokyoung Kim, Ji-Ho Park
Rok vydání:	2022
Předmět:	Inflammation Silicon Drug Carriers General Engineering General Physics and Astronomy Arthritis Rheumatoid Mice Methotrexate Nanomedicine Antirheumatic Agents Animals Calcium General Materials Science Porosity
Zdroj:	ACS Nano. 16:16118-16132
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.2c04491
Popis:	The lack of drugs that target both disease progression and tissue preservation makes it difficult to effectively manage rheumatoid arthritis (RA). Here, we report a porous silicon-based nanomedicine that efficiently delivers an antirheumatic drug to inflamed synovium while degrading into bone-remodeling products. Methotrexate (MTX) is loaded into the porous silicon nanoparticles using a calcium silicate based condenser chemistry. The calcium silicate-porous silicon nanoparticle constructs (pCaSiNPs) degrade and release the drug preferentially in an inflammatory environment. The biodegradation products of the pCaSiNP drug carrier are orthosilicic acid and calcium ions, which exhibit immunomodulatory and antiresorptive effects. In a mouse model of collagen-induced arthritis, systemically administered MTX-loaded pCaSiNPs accumulate in the inflamed joints and ameliorate the progression of RA at both early and established stages of the disease. The disease state readouts show that the combination is more effective than the monotherapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6776acb49a33d98074af9413f3f6fb https://doi.org/10.1021/acsnano.2c04491 Zobrazit plný text záznamu