Increase in Bone Mass Before Onset of Type 1 Diabetes Mellitus in Rats

Autor:	HARALAMBIEV, LYUBOMIR, NITSCH, ANDREAS, FISCHER, CORNELIUS S., LANGE, ANJA, KLÖTING, INGRID, STOPE, MATTHIAS B., EKKERNKAMP, AXEL, LANGE, JÖRN
Rok vydání:	2022
Předmět:	Pharmacology Cancer Research Diabetes Mellitus Type 1 Bone Density Animals Insulin Bone and Bones General Biochemistry Genetics and Molecular Biology Research Article Diabetes Mellitus Experimental Rats
Zdroj:	In Vivo
ISSN:	1791-7549 0258-851X
DOI:	10.21873/invivo.12805
Popis:	Background/Aim: The typical insulin deficiency in type 1 diabetes mellitus has general effects on metabolism and also affects bone quality. Materials and Methods: Two diabetic rat lines (BB/OK; BB.6KWR) and two non-diabetic rat strains (KWR and BB.14+18KWR), as control group, were included in the study. Bone mineral density, bone mineral content and body structure measurements were performed. The measurements took place before the onset of diabetes mellitus. Results: A comparison of the groups showed increased bone density values of the diabetic rats in relation to the control groups. A new finding of increased bone density in the diabetic rats occurs. Conclusion: Diabetic rats showed no osteoporotic bone metabolism before the onset of clinically relevant type 1 diabetes mellitus, but rather increased bone metabolic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d63fed1922fd0ea3008875c56c60cc6 https://doi.org/10.21873/invivo.12805 Zobrazit plný text záznamu