Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene
| Autor: | Diana Zelenika, Frédéric Jehan, Valérie Geoffroy, Anne Boland, Agnès Ostertag, Leila Lhaneche, Didier Hannouche, Bente L. Langdahl, Aline Domingues, Martine Cohen-Solal, Jannie Dahl Hald, Marc Delepine, Marie-Christine de Vernejoul, Torben Harsløf |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Genetic Markers Male medicine.medical_specialty Histology Bone density Adolescent Physiology Endocrinology Diabetes and Metabolism Gene Expression Biology Cohort Studies 03 medical and health sciences chemistry.chemical_compound Fractures Bone Young Adult Bone Density Internal medicine medicine Humans Epigenetics RNA Messenger Allele Adaptor Proteins Signal Transducing Aged Bone mineral Aged 80 and over Polymorphism Genetic Genetic Variation Methylation DNA Methylation Middle Aged Osteogenesis Imperfecta 030104 developmental biology Endocrinology chemistry CpG site DNA methylation Bone Morphogenetic Proteins Sclerostin Female |
| Zdroj: | Lhaneche, L, Domingues, A, Hannouche, D, Delepine, M, Zelenika, D, Boland, A, Ostertag, A, Cohen-Solal, M, Langdahl, B L, Harsløf, T, de Vernejoul, M-C, Geoffroy, V & Jehan, F 2016, ' Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene ', Bone, vol. 92, pp. 107-115 . https://doi.org/10.1016/j.bone.2016.08.004 |
| ISSN: | 1873-2763 |
| DOI: | 10.1016/j.bone.2016.08.004 |
| Popis: | SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samples from women, we found that rs851054 (G/A) is associated with SOST mRNA expression, donors with one or two G allele(s) displaying higher SOST expression (p |
| Databáze: | OpenAIRE |
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