Rationale and Design of F amily-Based A pproach in a M inority Community I ntegrating Systems–Bio l ogy for Promot i on of He a lth (FAMILIA)
| Autor: | Venkatesh Mani, Valentin Fuster, Eric E. Schadt, Maribel Santana, Zahi A. Fayad, Jacqueline Latina, Sameer Bansilal, Jason C. Kovacic, Chiara Giannarelli, Roger J. Hajjar, Andrew Kasarskis, Johan L.M. Björkegren, Rajesh Vedanthan, Risa Jaslow, Ana V. Soto, Samantha Sartori |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Counseling 0301 basic medicine Gerontology Health Knowledge Attitudes Practice New York Pilot Projects Health Promotion 030204 cardiovascular system & hematology Standard score Article Body Mass Index law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Surveys and Questionnaires Intervention (counseling) Early Intervention Educational Humans Medicine Cluster randomised controlled trial Exercise Health Education Minority Groups business.industry 030104 developmental biology Health promotion Cardiovascular Diseases Child Preschool Head start Health education Diet Healthy Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | American Heart Journal. 187:170-181 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/j.ahj.2017.02.020 |
| Popis: | Background The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease. Methods We plan to recruit 600 preschool children and their 600 parents or caregivers from 12-15 Head Start schools in Harlem, NY, and perform a 2:1 (2 intervention/1 control) cluster randomization of the schools. The preschool children will receive our intensive 37-hour educational program as the intervention for 4 months. For the adults, those in the "intervention" group will be randomly assigned to 1 of 2 intervention programs: an "individual-focused" or "peer-to-peer based." The primary outcome in children will be a composite score of knowledge (K), attitudes (A), habits (H), related to body mass index Z score (B), exercise (E), and alimentation (A) (KAH-BEA), using questionnaires and anthropometric measurements. For adults, the primary outcome will be a composite score for behaviors/outcomes related to blood pressure, exercise, weight, alimentation (diet) and tobacco (smoking; Fuster-BEWAT score). Saliva will be collected from the children for SNP genotyping, and blood will be collected from adults for RNA sequencing to identify network models and predictors of primary prevention outcomes. Conclusion The FAMILIA studies seek to demonstrate that targeting a younger age group (3-5 years) and using a family-based approach may be a critical strategy in promoting cardiovascular health across the life-span. |
| Databáze: | OpenAIRE |
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