Bacterial carriage and respiratory tract infections in subjects ≥ 60 years during an influenza season: implications for the epidemiology of Community Acquired Pneumonia and influenza vaccine effectiveness

Autor: Ansaldi, F., Florentiis, D., Parodi, V., Rappazzo, E., Coppelli, M., Martini, M., Cristiano Alicino, Durando, P., Icardi, G.
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Scopus-Elsevier
Popis: Introduction. During the 2010/11 influenza season an epidemio- logical prospective cohort active study was organized, to evalu- ate etiologic role due to the main bacteria and viruses causing Community Acquired Pneumonia (CAP) and Influenza like-illness (ILI) in elderly and to explore the role of the bacterial nose-phar- ingeal carriage in subjects with respiratory tract infections. Methods. An integrated active surveillance of a cohort of adults aged ? 60 y based on a double prospective and retrospective mechanisms of capture of ILI and CAP cases was organized. Sam- ples were collected from all ILI and CAP prospectively identified. The samples were be tested by multiplex PCR for detection of the main respiratory bacteria and viruses. Results and discussion. The study population amounted to 2,551 adults. During the 2010/11 influenza season, the ILI cumulative incidence was 4.2%, that was twice higher than that calculated by regional sentinel?based Influenza surveillance system dur- ing the 2010/11 season in the elderly (2.2%). Among 45 patients with ILI of which had been collected the swab, 17 (37.8%) were positive for influenza viruses and 2 (4.4%) for RSV, 6 (13.3%) patients carried Streptococcus pn and 6 (13.3%) Haemophilus in. In the same period, 7 CAP cases were observed; 3 cases were prospectively identified and samples were collected, while 4 cases were retrospectively detected. The CAP cumulative incidence was 0,3%. The influenza vaccine effectiveness in prevention of lab- oratory-confirmed influenza emerged by our study was 61%, in condition of good antigenic matching between vaccine and circu- lating strains observed during the 2010/11. These data contribute to better defining the epidemiological picture of upper and lower respiratory tract infections, fundamental information in light of the recent introduction of new vaccines for prevention of pneumo- nia in the elderly, including 13-valent conjugate pneumococcal vaccine. The full article is free available on www.jpmh.org
Journal of Preventive Medicine and Hygiene, Vol 53, No 2 (2012)
Databáze: OpenAIRE
Externí odkaz: