Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer
| Autor: | Ryotaro Yamamoto, Takuya Nonomura, Kunishige Onuma, Yoshiyuki Uruma, Marie Edatani, Priscilla Yoong Mei Yen, Futoshi Okada |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Proton Magnetic Resonance Spectroscopy
medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Nanotechnology Photodynamic therapy Spectrometry Mass Fast Atom Bombardment 010402 general chemistry 01 natural sciences Biochemistry Mice chemistry.chemical_compound Furocoumarins Drug Discovery medicine Animals Photosensitizer Carbon-13 Magnetic Resonance Spectroscopy Molecular Biology Psoralen Biological evaluation Mice Inbred BALB C Photosensitizing Agents 010405 organic chemistry Organic Chemistry Water Cancer 3T3 Cells Photosensitizing Agent medicine.disease 0104 chemical sciences Photochemotherapy Solubility Design synthesis chemistry Drug Design Cancer cell Cancer research Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry. 25:2372-2377 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2017.02.050 |
| Popis: | In recent years, photodynamic therapy (PDT) has been approved for treating various medical conditions, including cancer. PDT is a treatment that employs a particular drugs, called photosensitizers which work along with specific light source. The growth of this medical industry is expanding as it is another promising alternative to treat cancer which lessen the burden of treatments in patients. This includes the benefits of minimally invasive procedures and delivering high accuracy in targeting mutations. In recent two decades, cancer researchers have produced remarkable studies on developing photosensitizers that enhance understanding of biology and genetics of cancer. It is unfortunate that not all PDT can work as well as other profound treatment because PDT has various limitations like PDT leads photosensitivity reaction that arises when the photosensitizer remains in the body for a long period of time. In this paper, our studies centers on synthesizing a highly soluble photosensitizing agent with improved effectiveness on detecting cancer cells. |
| Databáze: | OpenAIRE |
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