Von Brunn's Nests in the Ureters of Two Cats
| Autor: | Roberto Nannini, Patrizia Bassi, Giuliano Bettini, Gianfranco Militerno |
|---|---|
| Přispěvatelé: | Militerno, Gianfranco, Bassi, Patrizia, Bettini, Giuliano, Nannini, Roberto, Prof. Giuseppe Sarli, Prof. Cinzia Benazzi, Prof. Barbara Brunetti, Dr. Giancarlo Avallone, Militerno, G., Bassi, P., Bettini, G., Nannini R. |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty 040301 veterinary sciences Von Brunn's nests Von Brunn’s nests benign urothelial islands urinary bladder ureter cat Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Ureter Submucosa medicine Urothelium Lamina propria CATS Urinary bladder General Veterinary business.industry Von Brunn’s Nests Urothelium Ureter Neoplasms Histopathology Cat 04 agricultural and veterinary sciences Anatomy 030108 mycology & parasitology medicine.disease Transitional cell carcinoma medicine.anatomical_structure 030220 oncology & carcinogenesis Histopathology business |
| Zdroj: | Journal of Comparative Pathology. 156:88 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2016.11.109 |
| Popis: | Introduction - Von Brunn’s nests and cysts are submucosal benign urothelial processes, related to irritative stimuli. They are common findings in the urinary bladder of human beings. Very few cases have been described in dogs and cats. Materials and Methods - We report macroscopic, histopathological and, in one case, immunohistochemical features of these rare forms in the left ureters of two cats, after ureterectomy due to urinary obstruction. Results - In both cases, macroscopical findings were coherent with an isolated, nodular and compact mass of 2.5 cm diameter. Microscopic examination showed considerable thickening of the muscular wall due to multifocal fibrosis, multifocal lacking of the lining epithelium in transverse sections of the ureteral lumen, and foci of urothelial islands in the lamina propria without any cytological atypia or mitosis and with occasional central cystic cavities. Multifocal areas of oedema, hyperemia/hemorrhage, angiogenesis and mild to moderate widespread lymphoplasmacytic infiltrates were also present. The cystic cavities contained macrophages full of lipofuscin, hemosiderin, erythrocytes and eosinophilic amorphous material. In one case, urothelial islands showed intense immunoreactivity for pan-cytokeratin (CK AE1/AE3). Inflammation was poor in the other case, where the urothelium appeared multifocally dilated with focal mucous metaplasia. In both cases, such findings and the anamnesis allowed us to hypothesize that the presence of epithelial islands was consistent with a hyperplastic condition, known as von Brunn’s nests and cysts. Conclusions - It is important to know the histological features of von Brunn nests, since it is not always easy to distinguish these islands from a well-differentiated urothelial carcinoma. |
| Databáze: | OpenAIRE |
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