| Autor: |
Su, Shenghui, Tang, Qiangqiang, Qu, Dongbin |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Bioengineering and Biotechnology. 10 |
| ISSN: |
2296-4185 |
| DOI: |
10.3389/fbioe.2022.856986 |
| Popis: |
Zinc and its alloys are considered to be next-generation materials for fabricating absorbable biomedical devices. However, cytotoxicity has been reported to be associated with rapid degradation. To address these issues, a composite coating (PLA/Li-OCP) consisting of CaHPO4 conversion coating (Ca-P) and polylactic acid (PLA) decorated with Li-octacalcium phosphate particles was constructed on pure zinc. The immersion tests showed that the presence of Ca-P coating and PLA/Li-OCP coating on pure zinc could reduce the pH value. Compared with Ca-P coating, the introduction of the PLA/Li-OCP film on the Ca-P-coated samples could enhance the corrosion resistance, and there was one order of magnitude decrease in the corrosion current density. The cytocompatibility assay suggested that the PLA/Li-OCP coating favored the cell viability and upregulated the expression of related osteogenic-genes including RUNX2, OCN, and BMP. Therefore, the presence of the PLA/Li-OCP coating on pure zinc could effectively improve the degradation rate and cytocompatibility of pure zinc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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