Abnormal myocardial work in children with Kawasaki disease
| Autor: | Nunzia Borrelli, Elena Karagadova, Valentina Bucciarelli, Martina Avesani, Enrico Piccinelli, Josefa Paredes, Jethro Herberg, Jolanda Sabatino, Alain Fraisse, Maraisa Spada, Sylvia Krupickova, Giovanni Di Salvo, Ciro Indolfi, Manjit Josen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Longitudinal strain Science Heart Ventricles Cardiology Work efficiency Systolic function Mucocutaneous Lymph Node Syndrome 030204 cardiovascular system & hematology Article 030218 nuclear medicine & medical imaging 03 medical and health sciences High morbidity 0302 clinical medicine Internal medicine Pressure Humans Medicine Preschool Child Multidisciplinary Ejection fraction business.industry Myocardium Infant Newborn Infant Reproducibility of Results Stroke Volume Newborn medicine.disease Magnetic Resonance Imaging Cardiovascular diseases medicine.anatomical_structure Echocardiography Child Preschool Female Kawasaki disease business Artery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| Popis: | Kawasaki disease (KD) can be associated with high morbidity and mortality due to coronary artery aneurysms formation and myocardial dysfunction. Aim of this study was to evaluate the diagnostic performance of non-invasive myocardial work in predicting subtle myocardial abnormalities in Kawasaki disease (KD) children with coronary dilatation (CADL). A total of 100 patients (age 8.7 ± 5 years) were included: 45 children with KD and CADL (KD/CADL) (Z-score > 2.5), 45 age-matched controls (CTRL) and, finally, an additional group of 10 children with KD in absence of coronary dilatation (KD group). Left ventricular (LV) systolic function and global longitudinal strain (GLS) were assessed. Global myocardial work index (MWI) was calculated as the area of the LV pressure-strain loops. From MWI, global Constructive Work (MCW), Wasted Work (MWW) and Work Efficiency (MWE) were estimated. Despite normal LV systolic function by routine echocardiography, KD/CADL patients had lower MWI (1433.2 ± 375.8 mmHg% vs 1752.2 ± 265.7 mmHg%, p . MWI, MCW and MWE were significantly reduced in KD children despite normal LVEF and normal GLS. These abnormalities seems independent from CADL. Thus, in KD with normal LVEF and normal GLS, estimation of MWI may be a more sensitive indicator of myocardial dysfunction. |
| Databáze: | OpenAIRE |
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