Evaluation of sampling locations in pregnant women and newborns for the detection of colonisation with antibiotic-resistant bacteria
Autor: | A. C. Adler, B Karlin, L Schomacher, Uta Ochmann, Giuseppe Valenza, M Zamfir, M Franitza, L Nasri, Caroline Herr, C Tuschak, Stefan Hörmansdorfer, A Dammeyer, Stefanie Kolb |
---|---|
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Staphylococcus aureus Adolescent 030106 microbiology medicine.disease_cause Asymptomatic Specimen Handling 03 medical and health sciences Young Adult 0302 clinical medicine Medical microbiology Antibiotic resistance Pregnancy Surveys and Questionnaires Drug Resistance Bacterial Escherichia coli Medicine Humans Sampling (medicine) 030212 general & internal medicine Pregnancy Complications Infectious business.industry Obstetrics Infant Newborn General Medicine Bacterial Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses Perianal region Surgery Colonisation Infectious Diseases Cross-Sectional Studies Carrier State Female Sample collection medicine.symptom business |
Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 36(10) |
ISSN: | 1435-4373 |
Popis: | Up to now, little has been known about the prevalence and clinical relevance of colonisation of asymptomatic pregnant women with methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA) or extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. In this two-centre cross-sectional study, we evaluated the performance and importance of screening at different times and different locations for colonisation in pregnant women and newborns. Between October 2013 and December 2015, four samples were collected from pregnant women, two from newborns at birth and three from 3-day-old newborns. Samples were screened on culturing media and were confirmed with molecular methods. MSSA was used as a surrogate for MRSA, as the two share most microbiologic characteristics and colonisation patterns. Of 763 pregnant women, 14.5% (111) were colonised with MSSA, 0.4% (3) with MRSA and 2.6% (20) with ESBL-producing E. coli. Of 658 newborns, 0.9% (10) were colonised with MSSA at birth and 13.1% (70) at 3 days old, 0.5% (3) were colonised with MRSA and 2.6% (17) with ESBL-producing E. coli. Nasal sampling identified 91.0% of MSSA-colonised pregnant women and 60.0% of newborns. In newborns, nasal and umbilical sampling at 3 days after birth discovered 84.0% of colonised cases. For ESBL-producing E. coli, the perianal region was positive in all colonised pregnant women and in 88.2% of colonised newborns. Combining nasal and perianal swabs is optimal when screening for antibiotic-resistant bacteria in pregnant women. Nasal, perianal and umbilical sample collection from 3-day-old newborns significantly increased the sensitivity compared to screening immediately after birth. |
Databáze: | OpenAIRE |
Externí odkaz: |