Resting and exercise cardiorespiratory function in survivors of congenital diaphragmatic hernia

Autor: Desmond Bohn, Ian Adatia, Donna L. Wilkes, Jane Schneiderman-Walker, Allan L. Coates, Daniel Trachsel, Hiran Selvadurai
Rok vydání: 2006
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Adolescent
Diaphragmatic breathing
Physical exercise
Pulmonary function testing
Cardiovascular Physiological Phenomena
Cohort Studies
Oxygen Consumption
Heart Rate
Internal medicine
Forced Expiratory Volume
medicine
Humans
Diaphragmatic hernia
Body Weights and Measures
Exertion
Survivors
Cardiac Output
Child
Hernia
Diaphragmatic
Exercise Tolerance
business.industry
Pulmonary Gas Exchange
Congenital diaphragmatic hernia
Cardiorespiratory fitness
Stroke Volume
medicine.disease
Pulmonary hypertension
Respiratory Function Tests
Residual Volume
Cross-Sectional Studies
Pediatrics
Perinatology and Child Health
Physical therapy
Cardiology
Exercise Test
Respiratory Physiological Phenomena
Female
business
Hernias
Diaphragmatic
Congenital
Lung Volume Measurements
Zdroj: Pediatric pulmonology. 41(6)
ISSN: 8755-6863
Popis: Our objective was to study exercise capacity and cardiorespiratory response to exertion in survivors of congenital diaphragmatic hernia (CDH). This was a cross-sectional cohort study of 23 CDH survivors, aged 10-16 years, and 23 gender- and age-matched controls. Exercise testing was performed on a cycle ergometer, with cardiac output measurements made using exponential CO2 rebreathing. Pretest cardiorespiratory assessment was done by echocardiography and pulmonary function testing. Statistical analysis was performed using Student's t-test, regression analysis, and longitudinal model computing with spatial covariance structure. No echocardiographic evidence for pulmonary hypertension was found at rest (right ventricular systolic pressures, 27 +/- 6 mmHg). Mean pulmonary artery diameter on the side of the CDH was significantly smaller than contralaterally, but was within normal range (z-score, 0 +/- 1.1 vs. 1.2 +/- 1.6, P < 0.01). Exercise capacity was mildly reduced in CDH compared to controls and predictive data (maximum workload, 77% +/- 12% vs. 91% +/- 16% of predicted, P < 0.01). Cardiorespiratory response to exertion was not significantly different between groups. In conclusion, most adolescent CDH survivors have nearly normal exercise capacity and cardiorespiratory response to exertion. This study may prove useful in comparisons with future cohorts comprising more severely affected individuals now surviving due to improved neonatal care.
Databáze: OpenAIRE
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