Alpha 2U-globulin: measurement in rat kidney and relationship to hyaline droplets
| Autor: | Michael G. Simpson, Michael D. Stonard, Edward A. Lock, Peter G.N. Phillips, John R. Foster |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Pathology medicine.medical_specialty Hyalin Globulin Renal cortex Clinical Biochemistry Alpha (ethology) urologic and male genital diseases Kidney Biochemistry Immunoenzyme Techniques Sex Factors Internal medicine Mole Alpha-Globulins medicine Animals Alpha globulin Hyaline biology Chemistry Histocytochemistry Biochemistry (medical) Kidney metabolism General Medicine Octanes Rats Endocrinology medicine.anatomical_structure biology.protein Female |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 160(2) |
| ISSN: | 0009-8981 |
| Popis: | The concentration of renal alpha 2U-globulin increased in a dose-dependent manner in adult male but not female rats which received a single dose of 2,2,4-trimethylpentane (TMP). After administration of a single dose of 12 mmol TMP/kg to adult male rats, the renal concentration of alpha 2U-globulin reached a peak at 48 hours and returned to near background level after 7 days. These changes in renal alpha 2U-globulin concentration were closely paralleled by changes in renal hyaline droplet formation. Renal alpha 2U-globulin and hyaline droplets were absent in normal pre-puberty male rats, and neither could be stimulated by a single dose of TMP. alpha 2U-Globulin was localised in the renal cortex of adult male rats, in particular the S2 segment of the proximal tubule. A greater staining intensity due to alpha 2U-globulin was seen in the S2 and adjacent segments after a single dose of TMP. A strong association is suggested between the presence of renal hyaline droplets and the occurrence of alpha 2U-globulin. |
| Databáze: | OpenAIRE |
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