The association between walking speed from short- and standard-distance tests with the risk of all-cause mortality among adults with radiographic knee osteoarthritis: data from three large United States cohort studies
| Autor: | Y.M. Golightly, Rebecca J. Cleveland, Yuqing Zhang, Louise M. Thoma, Meredith B. Christiansen, Jason T. Jakiela, Hiral Master, Cora E. Lewis, Michael P. LaValley, Dana Voinier, Daniel K. White, Leigh F. Callahan, Michael C. Nevitt, Tuhina Neogi, Amanda E. Nelson, Laura Frey-Law |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Population Biomedical Engineering Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Humans Medicine Orthopedics and Sports Medicine Longitudinal Studies Mortality education Aged 030203 arthritis & rheumatology education.field_of_study business.industry Proportional hazards model Hazard ratio Middle Aged Osteoarthritis Knee United States Confidence interval Walking Speed Preferred walking speed 030104 developmental biology Difficulty walking Cohort Physical therapy Female business human activities Cohort study |
| Zdroj: | Osteoarthritis Cartilage |
| ISSN: | 1063-4584 |
| Popis: | OBJECTIVE: Adults with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may modify this relation. Little is known about specific aspects of walking difficulty that increase mortality risk. We investigated the association of walking speed (objective measure of walking difficulty) with mortality and examined the threshold that best discriminated this risk in adults with rKOA. METHODS: Participants with rKOA from the Johnston County Osteoarthritis Project (JoCoOA, longitudinal population-based cohort), Osteoarthritis Initiative and Multicenter Osteoarthritis Study (OAI and MOST, cohorts of individuals with or at high risk of knee OA) were included. Baseline speed was measured via 2.4-meter (m) walk test (short-distance) in JoCoOA and 20-m walk test (standard-distance) in OAI and MOST. To examine the association of walking speed with mortality risk over nine years, hazard ratios (aHR) and 95% confidence intervals (CI) were calculated from Cox regression models adjusted for potential confounders., A Maximal Likelihood Ratio Chi-square Approach was utilized to identify an optimal threshold of walking speed predictive of mortality. RESULTS: Deaths after 9 years of follow-up occurred in 23.3% (290/1244) of JoCoOA and 5.9% (249/4215) of OAI+MOST. Walking 0.2 meters/second slower during short- and standard-distance walk tests was associated with 23% (aHR[95%CI]; 1.23[1.10, 1.39]) and 25% (1.25[1.09, 1.43]) higher mortality risk, respectively. Walking |
| Databáze: | OpenAIRE |
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