Urinary biomarkers for lupus nephritis: the role of the vascular cell adhesion molecule-1

Autor:	G. Levi Três, N. Pamplona Bueno de Andrade, Odirlei André Monticielo, Francisco José Veríssimo Veronese, Andrese Aline Gasparin, Vanessa Hax
Rok vydání:	2019
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Lupus nephritis Vascular Cell Adhesion Molecule-1 Urine Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Humans Medicine VCAM-1 Cell adhesion 030203 arthritis & rheumatology medicine.diagnostic_test business.industry Cell adhesion molecule Urinary biomarkers medicine.disease Lupus Nephritis 030104 developmental biology chemistry Case-Control Studies Renal biopsy business Biomarkers
Zdroj:	Lupus. 28:265-272
ISSN:	1477-0962 0961-2033
Popis:	Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predict disease activity and renal histology, but also lead to earlier treatment. In previous studies, the soluble vascular cell adhesion molecule-1 measured in urine showed a strong association with the presence of lupus nephritis, with clinical and histological activity indexes of the disease and with more severe renal lesions. This paper reviews the main urinary biomarkers of lupus nephritis that have been studied, with special emphasis on vascular cell adhesion molecule-1 results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d53846e7e32982a39c1ea887c66d311 https://doi.org/10.1177/0961203319826695 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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