Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients
| Autor: | Yong Chen, Hua-Fang Bao, Lin Qi, Dan Luo, Jing-Fen Ye, Jian-Fei Cai, Yan Shen, Hai-Fen Ma, Jun Zou, Jian-Long Guan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Medicine (General) Physiology QH301-705.5 Immunology Biophysics Ocean Engineering Disease Behcet's disease Anterior uveitis recurrence Biochemistry Gastroenterology Uveitis 03 medical and health sciences 0302 clinical medicine R5-920 Recurrence Risk Factors Internal medicine medicine Humans Serum amyloid A General Pharmacology Toxicology and Pharmaceutics Biology (General) Triglycerides Receiver operating characteristic business.industry General Neuroscience Behcet Syndrome Low-density lipoprotein Area under the curve Cell Biology General Medicine medicine.disease 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis Intermediate uveitis Female Oral ulcers business Behcet’s disease Lipoprotein Research Article |
| Zdroj: | Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.53 n.6 2020 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| ISSN: | 1414-431X 0100-879X |
| Popis: | This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the "International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease". In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969-0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease. |
| Databáze: | OpenAIRE |
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