Patient-Reported Outcomes After Platelet-Rich Plasma, Bone Marrow Aspirate, and Adipose-Derived Mesenchymal Stem Cell Injections for Symptomatic Knee Osteoarthritis

Autor: Marianela Di Tomaso, Jose L. Decima, Javier Roberti, Esteban J. Estrada, Marcelo Rodríguez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, Vol 13 (2020)
Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
ISSN: 1179-5441
Popis: Objective: The objective of this study was to compare platelet-rich plasma (PRP), bone marrow aspirate concentrate (BMAC), and adipose-derived mesenchymal stem cell (MSC) injections in the treatment of osteoarthritis (OA) of the knee using functional scores. Methods: A total of 89 patients with painful knee OA were included in this study. Patients were assigned to one of the 3 treatments according to severity of OA as indicated by symptoms and radiography to PRP (stage I), BMAC (stage II), or adipose-derived MSC (stage III). Clinical assessment was performed using the Knee Society Score, which combines the Knee Score, based on the clinical parameters, and the Functional Score, and IKDC score. Surveys were completed at preoperative and at 90, 180, and 265 days postoperative. The follow-up responses were compared with baseline and between treatment groups. Results: Treatment with PRP, BMAC, and adipose-derived MSC included 29 (32.6%), 27 (30.3%), and 33 (37.1%) patients, respectively. For the total group, median age was 61 years (range: 22-84 years). Score values were comparable among treatment groups at baseline. Statistically significant improvement was observed in the 3 groups according to the 3 scores at all time points during follow-up compared with baseline. No difference was found among treatment type. Conclusions: Our findings support previous reports and encourage further research on the use of these cost-effective treatments for OA of the knee. Fil: Estrada, Esteban. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina Fil: Décima, Jose L.. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina Fil: Rodríguez, Marcelo. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina Fil: Di Tomaso, Marianela. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina Fil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Gobierno de la Provincia de San Luis. Hospital Policlinico Regional Juan Domingo Peron.; Argentina
Databáze: OpenAIRE
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