Thymoglobulin Induction Therapy in Deceased Donor Kidney Transplantation: Single-Center Experience in Mexico
| Autor: | Ernesto Soto-Miranda, D. Avila y Falfan, Gustavo Martínez-Mier, Luis F Budar-Fernández, A. Uscanga-Montesano, A. Gomez-Diaz, L.J. Mateu-Rivera, María Fernanda Trujillo-Martínez |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Delayed Graft Function Kaplan-Meier Estimate Single Center Young Adult Humans Medicine Child Adverse effect Mexico Survival rate Dialysis Kidney transplantation Antilymphocyte Serum Retrospective Studies Transplantation Thymoglobulin business.industry Incidence Graft Survival Retrospective cohort study Middle Aged medicine.disease Kidney Transplantation Tissue Donors Surgery Survival Rate Treatment Outcome Female business |
| Zdroj: | Transplantation Proceedings. 48:596-599 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2016.02.018 |
| Popis: | Background Induction therapy is used to reduce the incidence of graft rejection and delayed graft function. Thymoglobulin is the most used inductor agent in deceased donor kidney transplantation due to its lower rejection and delayed graft function rates. Methods Retrospective study of patients who underwent deceased donor kidney transplantation from 2011 to 2014. Efficacy and safety outcomes evaluated were primary graft nonfunction, delayed graft function, acute rejection episodes, the lowest leukocyte count during the induction, adverse effects, eGFR, and patient and graft survival. P Results A total of 42 patients were registered. Of these, 51.7% were female, with a mean age of 36.4 ± 11.1 years. Mean dialysis time was 112.4 ± 365 months. Mean donor age was 33.7 ± 13.1 years. Of the registered patients, 14.3% were extended criteria donors and 23.8% high-risk. Mean thymoglobulin dose was 4.4 ± 0.8 mg/kg. Primary graft nonfunction was 2.4%. Nineteen percent presented with delayed graft function and 19% with acute rejection. Mean lowest leukocyte count was of 4.6 ± 1.5 × 103 cells/mm3. Mean hospital stay was 11.3 ± 6.3 days. Adverse effects were seen in 59.5% of registered patients, whereas graft survival 1 year and 3 years after transplantation was 85.3% and 56.9%, respectively. Patient survival 1 year and 3 years after transplantation was 85.3% and 53.8%, respectively. Patients who received a higher dose (>4.4 mg/kg) had a shorter hospital stay (9.4 ± 4.6 and 8.1 ± 2.3) than those who received lower dose (13.6 ± 7.9 and 12.8 ± 7.4; P Conclusion Thymoglobulin induction at doses near 5 mg/kg in deceased donor kidney transplant is efficient and secure at our center. |
| Databáze: | OpenAIRE |
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