Compassionate Use of Rectal Ozone (O3) in Severe COVID-19 Pneumonia: a Case-Control Study
| Autor: | Maria Jesus Albaladejo-Florin, Javier Rodríguez-de-Cía, Juan Gallego-Galiana, Daiana Peña-Lora, Enrique Pacios, David E Torres-García, Gerardo Fabiel Pérez-Cruz, Sandra Alava-Rabasa, Luz Otilia Casique-Bocanegra, María Jesús López-Muñoz, Isabel Usandizaga-Elio, Olga Susana Pérez-Moro, Marcos Edgar Fernandez-Cuadros |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ozone business.industry Mortality rate SARS-Cov-2 Case-control study General Medicine Pneumonia Rectal insufflation Ozone therapy Fibrinogen medicine.disease Gastroenterology chemistry.chemical_compound chemistry Internal medicine medicine business Covid-19 Dexamethasone medicine.drug Pneumonitis |
| Zdroj: | Sn Comprehensive Clinical Medicine |
| ISSN: | 2523-8973 |
| Popis: | Objectives: To evaluate effect of rectal Ozone in severe COVID-19 pneumonia and to compare to Standard-of-care (SOC). Material and Methods: In a case-control study, 14 patients with severe bilateral COVID-19 pneumonia (positive RT-PCR), treated with SOC and rectal Ozone, were evaluated before-and-after treatment and compared with SOC (14 patients) in a 10 day follow-up period. Ozone-protocol consisted of 8 sessions (1 session/day) of intra-rectal Ozone, (150mL volume, 35mg/ml concentration [5.25mg total dose]). The SOC-protocol included O 2- supply, antivirals (Remdesivir), corticosteroids (Dexamethasone/Metilprednisolone), monoclonal antibodies (Anakinra/Tocilizumab), antibiotics (Azytromicine), anticoagulants (Enoxaparine) and hyperimmune serum (if necessary). Primary outcome variables: a) clinical (O 2- saturation and O 2- supply); b) biochemical (Lymphocyte count, Fibrinogen, D-Dimer, Urea, Ferritin, LDH, IL-6 and CRP); c) radiological Taylor Scale. Secondary outcome variables: a) hospitalization length-of-stay, b) mortality-rate. Results: At baseline, Ozone/SOC-groups were not different on age, comorbidities, O 2 -saturation and O 2 -supply. Patients in Ozone-Group improved O 2- saturation and decrease O 2- supply. SOC maintained O 2- saturation and required more O 2- supply. Lymphocyte-count improved only in Ozone-group and with statistical difference (pConclusion: Compassionate use of Rectal Ozone improved O 2 -saturation, reduced O 2 -supply, decreased inflammation biomarkers and improved Taylor’s radiological scale significantly when compared to SOC-Group. Mortality and length-of-stay was inferior in the Ozone-group, but this difference was not significant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink