Virus Infection and Death Receptor-Mediated Apoptosis
| Autor: | Shuai Liu, Zhongshun Liu, Xiao-zhen Liang, Wenbo Jiang, Xingchen Zhou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Viral pathogenesis viruses lcsh:QR1-502 Apoptosis Review Biology Virus Replication lcsh:Microbiology Virus Receptors Tumor Necrosis Factor 03 medical and health sciences Viral Proteins 0302 clinical medicine Immune system Virology virus infection Humans Gene Immune Evasion Host (biology) extrinsic apoptosis Receptor-mediated endocytosis Receptors Death Domain host immune response 030104 developmental biology Infectious Diseases Virus Diseases 030220 oncology & carcinogenesis Immunology Host-Pathogen Interactions Viruses death receptor Tumor necrosis factor alpha Signal Transduction |
| Zdroj: | Viruses Viruses, Vol 9, Iss 11, p 316 (2017) |
| ISSN: | 1999-4915 |
| Popis: | Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor necrosis factor family mediate this process. They either assist persistent viral infection or elicit the elimination of infected cells by the host. Death receptor-mediated apoptosis plays an important role in viral pathogenesis and the host antiviral response. Many viruses have acquired the capability to subvert death receptor-mediated apoptosis and evade the host immune response, mainly by virally encoded gene products that suppress death receptor-mediated apoptosis. In this review, we summarize the current information on virus infection and death receptor-mediated apoptosis, particularly focusing on the viral proteins that modulate death receptor-mediated apoptosis. |
| Databáze: | OpenAIRE |
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