Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells

Autor:	Laurent Gapin, Joyce T. Tan, Brea Bondi-Boyd, Jonathan Sprent, Charles D. Surh, William C. Kieper, Rhodri Ceredig
Jazyk:	angličtina
Rok vydání:	2002
Předmět:	mice T cell Immunology T lymphocytes Interleukin Biology Major histocompatibility complex Molecular biology Article cytokines Interleukin 21 medicine.anatomical_structure Interleukin 15 homeostasis medicine biology.protein Immunology and Allergy Cytotoxic T cell CD8 Interleukin 3 transgenic
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538 0022-1007
Popis:	Transgenic (TG) mice expressing a high copy number of interleukin (IL)-7 cDNA under the control of the major histocomaptability complex (MHC) class II promoter display a 10–20-fold increase in total T cell numbers. Here, we show that the increase in T cell numbers in IL-7 TG mice is most apparent at the level of memory phenotype CD44hi CD122hi CD8+ cells. Based on studies with T cell receptor (TCR) TG mice crossed to IL-7 TG mice, increased levels of IL-7 may provide costimulation for TCR recognition of self-MHC ligands and thus cause naive CD8+ cells to proliferate and differentiate into memory phenotype cells. In addition, a marked increase in CD44hi CD122hi CD8+ cells was found in IL-7 TG IL-15− mice. Since these cell are rare in normal IL-15− mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4e07340cce5e13892d491136a074ce http://europepmc.org/articles/PMC2193553 Zobrazit plný text záznamu