Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study
Autor: | Harvey J. Cohen, Martine Extermann, Tim A. Ahles, Arti Hurria, Danielle Tometich, Brent J. Small, Jeanne S. Mandelblatt, Claudine Isaacs, Heather S. L. Jim, Asma Dilawari, James C. Root, Andrew J. Saykin, George Luta, Deena Graham, Sunita K. Patel, Jaeil Ahn, Xingtao Zhou, Brenna C. McDonald, Judith E. Carroll, Wanting Zhai, Paul B. Jacobsen, Neelima Denduluri |
---|---|
Rok vydání: | 2019 |
Předmět: |
Sleep Wake Disorders
Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal Heart Diseases Health Status medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Survivorship Anxiety Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Survivorship curve Internal medicine medicine Humans 030212 general & internal medicine Exercise Life Style Fatigue Depression (differential diagnoses) Aged Aged 80 and over Depression business.industry Cancer Cancer Pain Middle Aged Center for Epidemiologic Studies Depression Scale Symptom Flare Up medicine.disease Oncology 030220 oncology & carcinogenesis Female Self Report Hormone therapy Nervous System Diseases Symptom Assessment medicine.symptom Cognition Disorders business Body mass index |
Zdroj: | Cancer |
ISSN: | 1097-0142 0008-543X |
Popis: | BACKGROUND Little is known about longitudinal symptom burden, its consequences for well-being, and whether lifestyle moderates the burden in older survivors. METHODS The authors report on 36-month data from survivors aged ≥60 years with newly diagnosed, nonmetastatic breast cancer and noncancer controls recruited from August 2010 through June 2016. Symptom burden was measured as the sum of self-reported symptoms/diseases as follows: pain (yes or no), fatigue (on the Functional Assessment of Cancer Therapy [FACT]-Fatigue scale), cognitive (on the FACT-Cognitive scale), sleep problems (yes or no), depression (on the Center for Epidemiologic Studies Depression scale), anxiety (on the State-Trait Anxiety Inventory), and cardiac problems and neuropathy (yes or no). Well-being was measured using the FACT-General scale, with scores from 0 to 100. Lifestyle included smoking, alcohol use, body mass index, physical activity, and leisure activities. Mixed models assessed relations between treatment group (chemotherapy with or without hormone therapy, hormone therapy only, and controls) and symptom burden, lifestyle, and covariates. Separate models tested the effects of fluctuations in symptom burden and lifestyle on function. RESULTS All groups reported high baseline symptoms, and levels remained high over time; differences between survivors and controls were most notable for cognitive and sleep problems, anxiety, and neuropathy. The adjusted burden score was highest among chemotherapy-exposed survivors, followed by hormone therapy-exposed survivors versus controls (P |
Databáze: | OpenAIRE |
Externí odkaz: |