Symptom burden among older breast cancer survivors: The Thinking and Living With Cancer (TLC) study

Autor: Harvey J. Cohen, Martine Extermann, Tim A. Ahles, Arti Hurria, Danielle Tometich, Brent J. Small, Jeanne S. Mandelblatt, Claudine Isaacs, Heather S. L. Jim, Asma Dilawari, James C. Root, Andrew J. Saykin, George Luta, Deena Graham, Sunita K. Patel, Jaeil Ahn, Xingtao Zhou, Brenna C. McDonald, Judith E. Carroll, Wanting Zhai, Paul B. Jacobsen, Neelima Denduluri
Rok vydání: 2019
Předmět:
Sleep Wake Disorders
Cancer Research
medicine.medical_specialty
Antineoplastic Agents
Hormonal
Heart Diseases
Health Status
medicine.medical_treatment
Antineoplastic Agents
Breast Neoplasms
Survivorship
Anxiety
Article
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Breast cancer
Cancer Survivors
Survivorship curve
Internal medicine
medicine
Humans
030212 general & internal medicine
Exercise
Life Style
Fatigue
Depression (differential diagnoses)
Aged
Aged
80 and over
Depression
business.industry
Cancer
Cancer Pain
Middle Aged
Center for Epidemiologic Studies Depression Scale
Symptom Flare Up
medicine.disease
Oncology
030220 oncology & carcinogenesis
Female
Self Report
Hormone therapy
Nervous System Diseases
Symptom Assessment
medicine.symptom
Cognition Disorders
business
Body mass index
Zdroj: Cancer
ISSN: 1097-0142
0008-543X
Popis: BACKGROUND Little is known about longitudinal symptom burden, its consequences for well-being, and whether lifestyle moderates the burden in older survivors. METHODS The authors report on 36-month data from survivors aged ≥60 years with newly diagnosed, nonmetastatic breast cancer and noncancer controls recruited from August 2010 through June 2016. Symptom burden was measured as the sum of self-reported symptoms/diseases as follows: pain (yes or no), fatigue (on the Functional Assessment of Cancer Therapy [FACT]-Fatigue scale), cognitive (on the FACT-Cognitive scale), sleep problems (yes or no), depression (on the Center for Epidemiologic Studies Depression scale), anxiety (on the State-Trait Anxiety Inventory), and cardiac problems and neuropathy (yes or no). Well-being was measured using the FACT-General scale, with scores from 0 to 100. Lifestyle included smoking, alcohol use, body mass index, physical activity, and leisure activities. Mixed models assessed relations between treatment group (chemotherapy with or without hormone therapy, hormone therapy only, and controls) and symptom burden, lifestyle, and covariates. Separate models tested the effects of fluctuations in symptom burden and lifestyle on function. RESULTS All groups reported high baseline symptoms, and levels remained high over time; differences between survivors and controls were most notable for cognitive and sleep problems, anxiety, and neuropathy. The adjusted burden score was highest among chemotherapy-exposed survivors, followed by hormone therapy-exposed survivors versus controls (P
Databáze: OpenAIRE
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