Multi-modal magnetic resonance elastography for noninvasive assessment of ovarian tissue rigidity in vivo
| Autor: | Teresa K. Woodruff, Charles D. Wood, Mayank Vijayvergia, Lonnie D. Shea, Charles Fasanati, Frank H. Miller, Timothy J. Carroll, L. Catherine Brinson |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Adolescent Biomedical Engineering Ovary Biology Biochemistry Palpation Article Biomaterials Elasticity Imaging Techniques Fibrosis medicine Animals Humans Ovarian Diseases Molecular Biology medicine.diagnostic_test Female infertility General Medicine medicine.disease Polycystic ovary Magnetic resonance elastography medicine.anatomical_structure Cattle Female Elastography Infertility Female Biotechnology |
| Zdroj: | Acta Biomaterialia. 13:295-300 |
| ISSN: | 1742-7061 |
| DOI: | 10.1016/j.actbio.2014.11.022 |
| Popis: | For centuries, physicians have relied on touch to palpate tissue and detect abnormalities throughout the body. While this time-tested method has provided a simple diagnostic exam for large, superficial abnormalities, it does not permit quantifiable measurements of stiffness in deeper, small organs. Advances in noninvasive imaging to measure tissue rigidity represent important extensions of manual palpation techniques. Tissue fibrosis occurs with age in many organs; in the ovary, it is thought to be a marker of polycystic ovary syndrome (PCOS) and age-related idiopathic infertility, although quantitative assessment of fibrosis in this deep, abdominal tissue has not been possible. We used noninvasive methods to quantify ovarian tissue rigidity and clarify the role of tissue stiffness in reproductive health. With proper validation against accepted standards, noninvasive imaging techniques may become the quantitative counterpart to interior probing palpation methods and invasive (surgical) diagnoses, with applications across many clinical settings, including evaluation of adolescent and young adult ovarian function. |
| Databáze: | OpenAIRE |
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