MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects
| Autor: | Carla C. Judice, Catarina Bourgard, Fabio T. M. Costa, Letusa Albrecht, Ana Carolina A. V. Kayano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Plasmodium host cell 030231 tropical medicine Immunology lcsh:QR1-502 Cryptosporidiosis Cryptosporidium Context (language use) Review parasites Microbiology lcsh:Microbiology immune response Host-Parasite Interactions Apicomplexa 03 medical and health sciences 0302 clinical medicine Immune system Mirna expression microRNA Humans Parasite hosting cell host Genetics biology Host (biology) fungi biology.organism_classification Malaria MicroRNAs 030104 developmental biology Infectious Diseases Gene Expression Regulation Toxoplasma Toxoplasmosis Signal Transduction |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 6 (2016) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2016.00005 |
| Popis: | MicroRNAs (miRNAs), a class of small non-coding regulatory RNAs, have been detected in a variety of organisms ranging from ancient unicellular eukaryotes to mammals. They have been associated with numerous molecular mechanisms involving developmental, physiological and pathological changes of cells and tissues. Despite the fact that miRNA-silencing mechanisms appear to be absent in some Apicomplexan species, an increasing number of studies have reported a role for miRNAs in host-parasite interactions. Host miRNA expression can change following parasite infection and the consequences can lead, for instance, to parasite clearance. In this context, the immune system signaling appears to have a crucial role. |
| Databáze: | OpenAIRE |
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