Cytokines and serotonin transporter in patients with major depression
| Autor: | Chwen Cheng Chen, Yee Shin Lin, Shin Rung Wu, Chyi Huey Bai, Chiung Wen Tsao |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty medicine.medical_treatment Serotonergic Monocytes Fluoxetine Internal medicine mental disorders medicine Humans RNA Messenger Biological Psychiatry 5-HT receptor Serotonin transporter DNA Primers Serotonin Plasma Membrane Transport Proteins Pharmacology Depressive Disorder Major biology Reverse Transcriptase Polymerase Chain Reaction Middle Aged nervous system diseases Endocrinology Cytokine nervous system biology.protein Cytokines Female Cytokine secretion Serotonin Psychology Reuptake inhibitor Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30:899-905 |
| ISSN: | 0278-5846 |
| Popis: | Altered cytokine secretion as a mechanism in the etiology of depression is still obscure. The serotonin transporter (5-HTT) may play an important role in the termination of serotonergic neurotransmission by serotonin (5-HT) uptaking into presynaptic neurons and representing as an initial action site for selective 5-HTT reuptake inhibitors (SSRI). In our study, we evaluated whether cytokines and 5-HTT acted as biological markers for depression. Blood samples were collected from 42 participants. The differences in cytokine and 5-HTT mRNA expressions of leukocytes were assessed between the patients with major depression (n=20) and the healthy controls (n=22), along with the measurements prior and after treatment with a SSRI, fluoxetine, for 3 months in the follow-up patient group (n=8). The results revealed that the mRNA expressions of IL-1beta, IL-6, IFNgamma, TNFalpha, and 5-HTT were higher in the depressed patients than those of the healthy controls. The higher level of mRNA expressions of IFNgamma and 5-HTT diminished after fluoxetine treatment. Furthermore, we found a positive correlation between 5-HTT and cytokines mRNA expressions in total participants, which suggested that pro-inflammatory cytokines and 5-HTT might play critical roles in the pathogenesis of major depression and that their levels were affected by chronic treatment with 5-HTT inhibitors. |
| Databáze: | OpenAIRE |
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