Short-term pain reduction after low-dose radiotherapy in patients with severe osteoarthritis of the hip or knee joint: a cohort study and literature review
| Autor: | M. E. Maassen, B. Jong, B. B. Koc, Edwin J. P. Jansen, J. Buijsen, Martijn G. M. Schotanus, R. Borghans |
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| Přispěvatelé: | RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie |
| Rok vydání: | 2018 |
| Předmět: |
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Knee Joint medicine.medical_treatment Radiotherapy Planning Osteoarthritis Severity of Illness Index Osteoarthritis Hip 030218 nuclear medicine & medical imaging Cohort Studies 0302 clinical medicine Computer-Assisted 80 and over Orthopedics and Sports Medicine Prospective cohort study Tomography Pain Measurement Aged 80 and over Radiotherapy Dosage Middle Aged Osteoarthritis Knee Knee Joint/diagnostic imaging X-Ray Computed Eastern european Knee/classification 030220 oncology & carcinogenesis Female Hip Joint Low-dose radiotherapy Cohort study musculoskeletal diseases medicine.medical_specialty QUESTIONNAIRE Pain Osteoarthritis Hip/classification 03 medical and health sciences Hip Joint/diagnostic imaging RADIATION-THERAPY SKELETAL medicine Humans In patient Knee Patient Reported Outcome Measures Hip/classification Aged Hip business.industry Radiotherapy Planning Computer-Assisted medicine.disease Surgery Radiation therapy Pain reduction Osteoarthritis Knee/classification Irradiation business Tomography X-Ray Computed |
| Zdroj: | European Journal of Orthopaedic Surgery and Traumatology, 29(4), 843-847. Springer Verlag |
| ISSN: | 1432-1068 1633-8065 |
| Popis: | BACKGROUND: Low-dose radiotherapy (LDRT) for pain reduction in osteoarthritis (OA) is a frequently used treatment in Germany and Eastern European countries. The evidence on the effects of LDRT on pain in patients with OA remains unclear. This study evaluated the effect of LDRT on pain in patients with severe OA of the hip or knee joint.METHODS: This prospective study included a total of 16 joints in 12 patients (4 hips and 12 knees). The inclusion criteria were: patients older than 50 years, severe OA (Kellgren-Lawrence grade III-IV) of the hip or knee joint, patients not responding to conservative treatment and patients who are inoperable or not willing to undergo surgery. The joint was irradiated with a total dose of 6.0 Gray. The Numeric Rating Scale for pain (NRS-pain) and patient-reported outcome measures were obtained at pre-, 6, 13, 26, 39 and 52 weeks post-radiation. A decrease of two points on the NRS-pain was defined as clinical relevant.RESULTS: The median age of the included patients was 74 years (range 58-89). In 50% of the joints (n = 8, 3 hip and 5 knee joints), a clinical relevant difference in pain at 6 weeks post-radiation was observed. This clinical relevant difference decreased to 25% at 52 weeks post-radiation.CONCLUSION: LDRT showed a clinical relevant pain relief at 6 weeks after radiotherapy. The long-term effect of LDRT, however, was limited. A randomized placebo-controlled trial is necessary to assess the effect of LDRT on pain in patients with OA of the hip or knee joint. |
| Databáze: | OpenAIRE |
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