The proteasome controls ESCRT-III–mediated cell division in an archaeon
| Autor: | Sian Bray, Siân Culley, Anđela Šarić, Gautam Dey, Gabriel Tarrason Risa, Catherine Fan, Delyan R. Mutavchiev, Robertus A. M. de Bruin, Ricardo Henriques, Luca Pellegrini, Anne E. Hafner, Lena Harker-Kirschneck, Mairi L. Kilkenny, Fredrik Hurtig, Buzz Baum, Colin Davis, Dimitra Papatziamou, Ann-Christin Lindås, Ambrosius P. Snijders, Leticia Meneguello, André A. Pulschen, Nicholas P. Robinson, Peter Faull, Diorge P. Souza |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Sulfolobus acidocaldarius
Models Molecular Proteasome Endopeptidase Complex Cell division Archaeal Proteins macromolecular substances ESCRT Article Bortezomib 03 medical and health sciences 030304 developmental biology Cyclin 0303 health sciences Multidisciplinary Endosomal Sorting Complexes Required for Transport 030306 microbiology Kinase Chemistry DNA replication Cell cycle Cell biology Proteasome Proteolysis Proteasome Inhibitors Cell Division |
| Zdroj: | Science |
| Popis: | Proteasomal control of division in Archaea In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By studying cell division in an archaeal relative of eukaryotes, Tarrason Risa et al. identified a role for the proteasome in triggering cytokinesis by an archaeal ESCRT-III homolog. Cell division in this archaeon was driven by stepwise remodeling of a composite ESCRT-III–based division ring, where rapid proteasome-mediated degradation of one ESCRT-III subunit triggered the constriction of the remaining ESCRT-III–based copolymer. These data strengthen the case for the eukaryotic cell division machinery having its origins in Archaea. Science , this issue p. eaaz2532 |
| Databáze: | OpenAIRE |
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