Bioequivalence of two oral dosage forms prepared from different polymorphic modifications of tenoxicam
| Autor: | N. M. Gharaibeh, M. Sheikh Salem, Abd.E.M. Gharaibeh, H. N. Alkaysi, A. A. Badwant |
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| Rok vydání: | 1994 |
| Předmět: |
Drug
Male media_common.quotation_subject Chemistry Pharmaceutical Administration Oral Biological Availability Pharmacology Bioequivalence High-performance liquid chromatography Dosage form Piroxicam Pharmacokinetics Oral administration Tenoxicam Medicine Humans Pharmacology (medical) Chromatography High Pressure Liquid media_common Cross-Over Studies Polymorphism Genetic business.industry Anti-Inflammatory Agents Non-Steroidal Bioavailability Therapeutic Equivalency business medicine.drug |
| Zdroj: | Journal of clinical pharmacy and therapeutics. 19(3) |
| ISSN: | 0269-4727 |
| Popis: | SUMMARY The bioavailability of two pharmaceutical dosage forms formulated using different polymorphs of tenoxicam were compared. Serum levels of TNX were analysed using high performance liquid chromatography. The pharmacokinetic parameters were estimated following the oral administration of a single dose (20 mg) of the drug as two different polymorphs to 12 healthy volunteers. The differences between formulations were statistically insignificant. |
| Databáze: | OpenAIRE |
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