24-hour profiles of salivary progesterone
| Autor: | Susann Klein, Ralf C. Zimmermann, Torsten M. Delfs, Freimut A. Leidenberger, Olaf G.J. Naether, Patrick Fottrell |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Saliva Chronobiology Periodicity Obstetrics and Gynecology Luteal phase Biology Luteal Phase Circadian Rhythm Endocrinology medicine.anatomical_structure Reproductive Medicine Reference Values Internal medicine Plasma concentration medicine Pulse frequency Humans Female Circadian rhythm Luteinizing hormone Corpus luteum Progesterone |
| Zdroj: | Fertility and sterility. 62(5) |
| ISSN: | 0015-0282 |
| Popis: | Objectives To assess whether the known pulsatility of P secretion by the corpus luteum, which is detected in blood by P measurements, translates into fluctuations of saliva P concentrations, and to determine how well saliva P measurements reflect plasma P concentration. A second objective was to see whether there is a window in the luteal phase, where P secretion has reached its maximum capacity, but the amplitude is not very accentuated, which would be an ideal time to measure P. Design Twenty-one ovulatory women were randomly assigned to be studied on day 5, 7, or 8 after the luteinizing hormone surge. Blood samples were drawn every 20minutes, and saliva samples were obtained hourly over a 24-hour period. Comparison between saliva plasma P was performed, and pulse analysis of plasma P was done. Results The percent variation of saliva P concentration over a 24-hour period was much higher when compared with the percent variation of plasma P concentration over the same time period (saliva P: 149%; plasma P: 107%). Also, the ratio of saliva to plasma P varied significantly between individuals (range: 0.0050 to 0.0148). A single plasma P concentration (8:00a.m.) correlated better with the 24-hour mean plasma concentration than the respective single saliva value or the mean of two or three saliva samples (8:00a.m. and 12:00p.m.; 8:00a.m., 12:00p.m., and 8:00p.m.). Plasma pulse frequency, mean pulse interval, pulse width, pulse amplitude, and 24-hour mean P level did not differ between the 3 study days. Conclusions A single plasma P determination reflects more accurately 24-hour P secretion than repeated saliva P samples measured in the same individual. We could not identify a window in the luteal phase when P measurements are more representative of corpus luteum function. |
| Databáze: | OpenAIRE |
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