Helminth Glycans at the Host-Parasite Interface and Their Potential for Developing Novel Therapeutics

Autor:	Bunte, Myrna J.M., Schots, Arjen, Kammenga, Jan E., Wilbers, Ruud H.P.
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	helminths QH301-705.5 Mini Review biopharmaceuticals vaccines immunomodulation Biochemistry Genetics and Molecular Biology (miscellaneous) Biochemistry parasitic diseases glycans Molecular Biosciences EPS Laboratory of Nematology Biology (General) Molecular Biology Laboratorium voor Nematologie
Zdroj:	Frontiers in Molecular Biosciences 8 (2022) Frontiers in Molecular Biosciences, Vol 8 (2022) Frontiers in Molecular Biosciences Frontiers in Molecular Biosciences, 8
ISSN:	2296-889X
Popis:	Helminths are parasitic worms that have successfully co-evolved with their host immune system to sustain long-term infections. Their successful parasitism is mainly facilitated by modulation of the host immune systemviathe release of excretory-secretory (ES) products covered with glycan motifs such as Lewis X, fucosylated LDN, phosphorylcholine and tyvelose. Evidence is accumulating that these glycans play key roles in different aspects of helminth infection including interactions with immune cells for recognition and evasion of host defences. Moreover, antigenic properties of glycans can be exploited for improving the efficacy of anti-helminthic vaccines. Here, we illustrate that glycans have the potential to open new avenues for the development of novel biopharmaceuticals and effective vaccines based on helminth glycoproteins.
Databáze:	OpenAIRE
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