Ten-year results comparing mastectomy to excision and radiation therapy for ductal carcinoma in situ of the breast
| Autor: | Melvin J. Silverstein, Parvis Gamagami, William J. Colburn, A. Barth, Eugene D. Gierson, David N. Poller, James R. Waisman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Disease-Free Survival Intraductal Breast Carcinoma Internal medicine medicine Overall survival Humans In patient Prospective Studies skin and connective tissue diseases Nuclear grade Mastectomy Aged Aged 80 and over business.industry Carcinoma Ductal Breast Significant difference Middle Aged Ductal carcinoma Combined Modality Therapy Radiation therapy Female Radiology Neoplasm Recurrence Local business Carcinoma in Situ |
| Zdroj: | European Journal of Cancer. 31:1425-1427 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/0959-8049(95)00283-o |
| Popis: | The 10-year results of 300 patients with ductal carcinoma in situ (DCIS) without microinvasion are reported; 167 treated with mastectomy and 133 treated with excision and radiation therapy. There was a significant difference in disease-free survival at 10 years, in favour of those treated with mastectomy, 98% versus 81% (P = 0.0004). Multivariate analysis confirmed nuclear grade as the only significant predictor of local recurrence (P = 0.02) or invasive local recurrence (P = 0.03) in patients with DCIS treated with excision and radiation therapy. There was no difference in breast cancer-specific survival or overall survival between the two treatment groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect