Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models
| Autor: | Cyril B. Frank, Jillian E. Beveridge, Nigel G. Shrive, Mehdi Shekarforoush, David A. Hart |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Knee Joint
Rotation Anterior cruciate ligament Medial Collateral Ligament Knee 0206 medical engineering Biomedical Engineering Biophysics 02 engineering and technology Osteoarthritis Kinematics Correlation 03 medical and health sciences 0302 clinical medicine In vivo Screw axis medicine Animals Orthopedics and Sports Medicine Meniscectomy 030222 orthopedics Medial collateral ligament Sheep business.industry Anterior Cruciate Ligament Injuries Rehabilitation Anatomy musculoskeletal system medicine.disease 020601 biomedical engineering Gait Biomechanical Phenomena Disease Models Animal surgical procedures operative medicine.anatomical_structure Female business |
| Zdroj: | Journal of Biomechanics. 75:67-76 |
| ISSN: | 0021-9290 |
| DOI: | 10.1016/j.jbiomech.2018.04.046 |
| Popis: | The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints of two surgically induced injury sheep models: anterior cruciate ligament and medial collateral ligament transection (ACL/MCL Tx) (n = 5) and lateral meniscectomy (n = 5). We hypothesized that morphological damage in the experimental joints would be correlated to alterations in these kinematic variables. There was no strong evidence that morphological damage to the joints 20 weeks post ACL/MCL transection or meniscectomy was correlated with alterations in the finite helical axes variables. Nevertheless, significant correlations were found between the morphological damage to the joints and the magnitude of the change in the translation vectors after ACL/MCL transection (significant correlations (p = 0.005) during stance and trends (p 0.1) at all points analyzed during swing). It can be concluded that: (1) osteoarthritic-like morphological damage after ACL/MCL transection is more critically correlated to the absolute tibiofemoral translational change and (2) alterations in analyzed kinematic variables cannot solely define osteoarthritis risk after meniscal injuries. From a clinical perspective, our results suggest that the magnitude of the change in the translation vector, which is independent of the coordinate system and combines the effects of the three translational degrees of freedom, i.e. medial-lateral, anterior-posterior and inferior-superior, would be an osteoarthritis risk factor after ligament injury, and requires validation in humans. |
| Databáze: | OpenAIRE |
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