Modified Liujunzi Decoction (六君子汤) Alleviates Chemotherapy-Induced Anorexia in Advanced Non-Small Cell Lung Cancer: A Propensity Score Matched Case-Control Study

Autor: Xiaoshu Zhu, Lizhu Lin, Lingling Sun, Zhuang-Zhong Chen, Hezheng Lai
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
0211 other engineering and technologies
Antineoplastic Agents
02 engineering and technology
Traditional Chinese medicine
Anorexia
030226 pharmacology & pharmacy
Gastroenterology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Carcinoma
Non-Small-Cell Lung
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
021105 building & construction
medicine
Humans
Pharmacology (medical)
Propensity Score
Lung cancer
Cisplatin
Chemotherapy
business.industry
Case-control study
General Medicine
medicine.disease
Musculoskeletal Manipulations
Complementary and alternative medicine
Case-Control Studies
Propensity score matching
medicine.symptom
business
Drugs
Chinese Herbal
medicine.drug
Zdroj: Chinese Journal of Integrative Medicine. 26:256-262
ISSN: 1993-0402
1672-0415
DOI: 10.1007/s11655-020-3185-5
Popis: To evaluate the effect of Chinese herbal medicine formula, modified Liujunzi Decoction (六君子汤, MLJZT), for anorexia, utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer (NSCLC). The study adopted a propensity score-matched design based on a prospective database. From February 2016 to September 2017, patients with advanced NSCLC that received both cisplatin-based chemotherapy and MLJZT (IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone (control group). Changes in anorexia and weight, as well as side effects were evaluated per week within 4-cycle chemotherapy. Overall, 156 patients with advanced NSCLC that had received chemotherapy from our database were identified and 53 pairs were matched successfully. In total, 48.6% (50/53) of patients in the IM group had anorexia-improvement compared to 28.3% (15/53) of patients in the control group, and a total of 39.6% (21/53) of patients in the control group had a worsening of anorexia compared to only 7.8% (8/53) of patients in the IM group (P
Databáze: OpenAIRE
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