Clinical efficacy and safety of antifungal drugs for the treatment of Candida parapsilosis infections: a systematic review and network meta-analysis
| Autor: | Zhiming Shan, Lingzhi Jiang, Qingxian Zhang, Jielin Qin, Han Yang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
safety
Adult Male Microbiology (medical) medicine.medical_specialty Candida parapsilosis Antifungal Agents Antifungal drugs MEDLINE Microbiology law.invention clinical efficacy chemistry.chemical_compound Randomized controlled trial law Internal medicine medicine antifungal drugs Humans Clinical efficacy Aged Aged 80 and over biology business.industry Candidiasis General Medicine Middle Aged biology.organism_classification meta-analysis Treatment Outcome Systematic review chemistry Meta-analysis Female Drug Monitoring Caspofungin business Prevention Therapy and Therapeutics |
| Zdroj: | Journal of Medical Microbiology |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Antifungal drugs have already been established as an effective treatment option for Candida parapsilosis infections, but there is no universal consensus on the ideal target for clinical efficacy and safety of antifungal drugs for the treatment of C. parapsilosis infections. Few studies have directly compared the efficacies of antifungal drugs for the treatment of C. parapsilosis infections. We hypothesize that different antifungal drugs offer differing clinical efficacy and safety for the treatment of C. parapsilosis infections. We performed a comprehensive network meta-analysis on different strategies for C. parapsilosis infection treatment and compared the clinical efficacy and safety of antifungal drugs as interventions for C. parapsilosis infections. The Cochrane Database of Systematic Reviews, Medline, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Technology of Chongqing VIP database, Wan Fang Data, and SinoMed databases were searched to identify appropriate randomized trials. Among the extracted C. parapsilosis cases, the survival and death rates with treatment of C. parapsilosis infection were compared among groups treated with different antifungal drugs. According to the evidence-network analysis, echinocandins were a better choice than other drugs for treating C. parapsilosis infections, and more importantly, caspofungin showed a more preferable effect for decreasing the risk of 30 day mortality. In conclusion, this study systematically evaluated the effectiveness and safety of antifungal drugs for the purpose of helping clinicians choose the most appropriate antifungal drugs. Future studies with larger samples are needed to evaluate the effects of patient factors on the clinical efficacy and safety of antifungal drugs for C. parapsilosis infections. |
| Databáze: | OpenAIRE |
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