Testosterone-induced increase in libido in a patient with a loss-of-function mutation in the AR gene
| Autor: | Franziska Phan-Hug, James S Acierno, Nicolas J Niederländer, Andrea Messina, Federico Santoni, Nelly Pitteloud, Stefano La Rosa, Laura Marino |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Gonadoblastoma White medicine.disease_cause Diseases of the endocrine glands. Clinical endocrinology Internal medicine Internal Medicine medicine Genetics Testes Andrology Gene Testosterone June Libido Mutation Insight into Disease Pathogenesis or Mechanism of Therapy business.industry DNA-binding domain RC648-665 medicine.disease Androgen receptor Endocrinology Estrogen Female business Switzerland |
| Zdroj: | Endocrinology, Diabetes & Metabolism Case Reports Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-6 (2021) Endocrinology, diabetes & metabolism case reports, vol. 2021, no. 1 |
| Popis: | Summary Complete androgen-insensitivity syndrome (CAIS), a disorder of sex development (46,XY DSD), is caused primarily by mutations in the androgen receptor (AR). Gonadectomy is recommended due to the increased risk of gonadoblastoma, however, surgical intervention is often followed by loss of libido. We present a 26-year-old patient with CAIS who underwent gonadectomy followed by a significant decrease in libido, which was improved with testosterone treatment but not with estradiol. Genetic testing was performed and followed by molecular characterization. We found that this patient carried a previously unidentified start loss mutation in the androgen receptor. This variant resulted in an N-terminal truncated protein with an intact DNA binding domain and was confirmed to be loss-of-function in vitro. This unique CAIS case and detailed functional studies raise intriguing questions regarding the relative roles of testosterone and estrogen in libido, and in particular, the potential non-genomic actions of androgens. Learning points N-terminal truncation of androgen receptor can cause androgen-insensitivity syndrome. Surgical removal of testosterone-producing gonads can result in loss of libido. Libido may be improved with testosterone treatment but not with estradiol in some forms of CAIS. A previously unreported AR mutation – p.Glu2_Met190del (c.2T>C) – is found in a CAIS patient and results in blunted AR transcriptional activity under testosterone treatment. |
| Databáze: | OpenAIRE |
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