Low folate status, and MTHFR 677C T and MTR 2756A G polymorphisms associated with colorectal cancer risk in Thais: a case-control study
| Autor: | Songsak Petmitr, Jaranit Kaewkungwal, Pornpimol Panprathip, Rungsunn Tungtrongchitr, Karunee Kwanbunjan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Risk medicine.medical_specialty Colorectal cancer Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Colorectal adenoma 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase 03 medical and health sciences 0302 clinical medicine Endocrinology Folic Acid Internal medicine medicine Humans Methionine synthase Methylenetetrahydrofolate Reductase (NADPH2) Aged Aged 80 and over 030109 nutrition & dietetics Nutrition and Dietetics Polymorphism Genetic biology business.industry Case-control study Odds ratio (Methionine synthase) reductase Middle Aged medicine.disease Thailand MTRR digestive system diseases Methylenetetrahydrofolate reductase Case-Control Studies biology.protein Female business Colorectal Neoplasms |
| Zdroj: | Nutrition research (New York, N.Y.). 72 |
| ISSN: | 1879-0739 |
| Popis: | Folate plays essential roles in DNA synthesis, repair, and methylation; thus, folate status may affect carcinogenesis. Genetics polymorphisms involved in folate metabolisms have been linked with colorectal cancer (CRC) development. Therefore, we hypothesized that low folate status and related genetic polymorphisms are associated with higher risk of CRC. This case-control study enrolled 105 new cases of CRC, 101 of colorectal adenoma (CRA), and 182 controls from hospitals in Bangkok, Thailand, to examine the association between folate status and methylenetetrahydrofolate reductase (MTHFR) 677C T, methionine synthase (MTR) 2756A G, and methionine synthase reductase (MTRR) 66A G with the risk of CRC and CRA. Regarding CRC risk, the lowest quartile group of serum folate and folate intake had higher risk of CRC than the highest quartile group (odds ratio [OR] = 11.45, 95% confidence interval [CI] = 4.43-29.59) and (OR = 10.29, 95% CI = 4.17-25.41). The lowest quartile group of folate intake also had a higher risk of CRA (OR = 5.22, 95% CI = 2.19-6.09). Low red blood cell folate combined with MTHFR 677C T polymorphism statistically increased CRC risk (OR = 10.00, 95% CI = 1.36-73.42). Low folate status combined with MTR 2756A G significantly increased CRA risk (OR = 6.43, 95% CI = 1.38-29.94). Moreover, the risk of CRC was elevated with alcohol consumption and low exercise activity when combined with low folate status (P .05). This study supported the hypothesis that, in Thais, low folate status is associated with a higher risk of CRC, particularly among those with polymorphisms of the MTHFR 677C T and MTR 2756 A G genes. |
| Databáze: | OpenAIRE |
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