Colonic and systemic effects of extruded whole-grain sorghum consumption in growing Wistar rats
| Autor: | Raúl E. Cian, Emilce Elina Llopart, Silvina R. Drago, Muñoz María Elvira López-Oliva, Angela Zuleta, Adriana Ruth Weisstaub |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Antioxidant medicine.medical_treatment Glutathione reductase Medicine (miscellaneous) 0302 clinical medicine Intestinal Mucosa Glucuronidase chemistry.chemical_classification Whole Grains Nutrition and Dietetics biology Chemistry beta-Glucosidase Glutathione peroxidase food and beverages Hydrogen-Ion Concentration Catalase ANTIOXIDANT STATUS medicine.medical_specialty Otras Ingenierías y Tecnologías Colon NF-E2-Related Factor 2 030209 endocrinology & metabolism INGENIERÍAS Y TECNOLOGÍAS Satiation Alimentos y Bebidas Superoxide dismutase 03 medical and health sciences Internal medicine medicine Animals Rats Wistar COLON HEALTH Sorghum Glutathione Peroxidase 030109 nutrition & dietetics Superoxide Dismutase LIPID PROFILE biology.organism_classification WHOLE GRAIN Diet Rats Bioavailability Disease Models Animal Intestinal Diseases Endocrinology EXTRUDED SORGHUM Agronomy Apoptosis biology.protein |
| Zdroj: | British Journal of Nutrition. 118:589-597 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Colonic effects of extruded whole-grain sorghum diets were evaluated using a model of growing rats. In all, twenty-four male Wistar rats were fed control (C), extruded white sorghum (EWS) or red sorghum (ERS). Consumption of sorghum diets showed satiety properties, with reduction of caecal pH, and lower activity of β-glucosidase and β-glucuronidase enzymes. Decreased copper zinc superoxide dismutase and manganese superoxide dismutase and increased catalase and glutathione peroxidase levels were observed in colonic mucosa. The induction of antioxidant enzymes occurred through the activation of the nuclear factor erythroid 2-related factor 2 protein and its subsequent translocation into the nucleus. ERS was able to decrease the proliferation of proximal mucosa of colon, demonstrating a possible effect against colorectal tumourigenesis. EWS increased proliferation and also apoptosis, ensuring the re-establishment of homoeostasis of the colonic mucosa. No antioxidant systemic effect (serum or hepatic level) was observed. It is likely that despite the extrusion the low bioavailability of the phenolic compounds of sorghum diets caused them to exert mainly acute effects at the colon level. Extruded whole-grain sorghum is a good functional ingredient that might be promising in dietary prevention of intestinal diseases. Fil: Llopart, Emilce Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina Fil: Cian, Raúl Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina Fil: López Oliva Muñoz, María Elvira. Universidad Complutense de Madrid; España Fil: Zuleta, Angela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Weisstaub, Adriana Ruth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Tecnología de los Alimentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina |
| Databáze: | OpenAIRE |
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