Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID‐19 Vaccines
| Autor: | Laura E. Avena, Anthony Griffiths, Loek J. Eggermont, Sidi A. Bencherif, Lindsay G. A. McKay, Zachary J. Rogers, Thibault Colombani, Rebecca I. Johnson, Nadia Storm |
|---|---|
| Přispěvatelé: | Northeastern University [Boston], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Université de Technologie de Compiègne (UTC), Harvard University [Cambridge] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
COVID-19 Vaccines
General Chemical Engineering Science General Physics and Astronomy Medicine (miscellaneous) SARS‐CoV‐2 vaccine Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) Virus Mice Immune system Drug Delivery Systems COVID‐19 Medicine Animals General Materials Science neutralizing antibodies Neutralizing antibody Research Articles biology business.industry SARS-CoV-2 Immunogenicity General Engineering Antibody titer Immunity COVID-19 injectable cryogel 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences Vaccine Potency Immunization Immunology Models Animal biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Female Antibody 0210 nano-technology business oxygen severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccine Cryogels Research Article |
| Zdroj: | Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021) Advanced Science Advanced Science, Wiley Open Access, 2021, 8 (18), pp.2100316. ⟨10.1002/advs.202100316⟩ |
| ISSN: | 2198-3844 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to an unprecedented global health crisis, resulting in a critical need for effective vaccines that generate protective antibodies. Protein subunit vaccines represent a promising approach but often lack the immunogenicity required for strong immune stimulation. To overcome this challenge, we first demonstrate that advanced biomaterials can be leveraged to boost the effectiveness of SARS‐CoV‐2 protein subunit vaccines. Additionally, we report that oxygen is a powerful immunological co‐adjuvant and has an ability to further potentiate vaccine potency. In preclinical studies, mice immunized with an oxygen‐generating COVID‐19 cryogel‐based vaccine (O2‐CryogelVAX) exhibited a robust Th1 and Th2 immune response, leading to a sustained production of highly effective neutralizing antibodies against the virus. Even with a single immunization, O2‐CryogelVAX achieved high antibody titers within 21 days, and both binding and neutralizing antibody levels were further increased after a second dose. Engineering a potent vaccine system that generates sufficient neutralizing antibodies after one dose is a preferred strategy amid vaccine shortage. Our data suggest that this platform is a promising technology to reinforce vaccine‐driven immunostimulation and is applicable to current and emerging infectious diseases. This article is protected by copyright. All rights reserved |
| Databáze: | OpenAIRE |
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