Relation of Adiponectin to Cardiovascular Events and Mortality in Patients With Acute Coronary Syndrome
| Autor: | Hiroshi Ogawa, Hiroyuki Arashi, Hidekimi Nomura, Junichi Yamaguchi, Nobuhisa Hagiwara |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Body Mass Index 03 medical and health sciences 0302 clinical medicine Japan Predictive Value of Tests Risk Factors Cause of Death Internal medicine Clinical endpoint Humans Medicine In patient Prospective Studies Myocardial infarction Acute Coronary Syndrome Aged Hypolipidemic Agents Adiponectin business.industry Hazard ratio Prognosis medicine.disease Confidence interval Survival Rate Cardiology Female Cardiology and Cardiovascular Medicine business Body mass index Biomarkers Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 140:7-12 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2020.10.053 |
| Popis: | The association between serum adiponectin levels and cardiovascular events, particularly how adiponectin predicts the development of cardiovascular events and mortality in acute coronary syndrome (ACS) patients remains unresolved. Hence, we aimed to determine whether higher adiponectin levels predict cardiovascular events and mortality in these patients. Regression analyses were performed to clarify adiponectin's ability to predict cardiovascular events and mortality among 1,641 ACS patients. Subgroup analyses were performed according to gender, age, and body mass index (BMI). The primary end point was a composite of the first all-cause death, nonfatal myocardial infarction, or nonfatal stroke event. The secondary end point was all-cause death. Hazard ratios for the primary and secondary end points per 5-µg/ml increase in adiponectin levels were 1.31 (95% confidence interval [CI], 1.13 to 1.47; p = 0.0007) and 1.32 (95% CI, 1.13 to 1.51; p = 0.001), respectively. Higher adiponectin levels were associated with increased cardiovascular events in men, patients aged ≥65 years, and those with BMI25 kg/m |
| Databáze: | OpenAIRE |
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